CYP2B6

CYP2B6
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	3IBD, 3QOA, 3QU8, 3UA5, 4I91, 4RQL, 4RRT, 4ZV8
معین‌کننده‌ها
نام‌های دیگر	CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450, cytochrome P450 family 2 subfamily B member 6, Cytochrome P450 2B6
شناسه‌های بیرونی	OMIM: 123930 MGI: 88598 HomoloGene: 73894 GeneCards: CYP2B6
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	25,626,049 bp
هستی‌شناسی ژن
عملکرد ملکولی	• iron ion binding; • arachidonic acid epoxygenase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; • metal ion binding; • heme binding; • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • oxidoreductase activity; • steroid hydroxylase activity; • monooxygenase activity;
ترکیبات سلولی	• organelle membrane; • endoplasmic reticulum membrane; • membrane; • intracellular membrane-bounded organelle; • شبکه آندوپلاسمی; • سیتوپلاسم;
فرایند زیستی	• steroid metabolic process; • epoxygenase P450 pathway; • cellular ketone metabolic process; • xenobiotic metabolic process; • organic acid metabolic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1555
	13088
	ENSG00000197408
	ENSMUSG00000030483
	P20813
	P12791
	NM_000767
	NM_009999
	NP_000758
	ن/م
	مشاهده/ویرایش موش

سیتوکروم P450 2B6 آنزیمی است که در انسان توسط ژن CYP2B6 کدگذاری می‌شود. CYP2B6 عضوی از گروه آنزیم‌های سیتوکروم پی ۴۵۰ است و همراه با CYP2A6 و همراه با بسیاری از مواد دیگر در متابولیسم نیکوتین نقش دارد.

لیگاندها

بسترها	مهارکننده‌ها	القاکننده‌ها
آلفنتانیل (مواد افیونی ضد درد) بوپروپیون (داروهای ضدافسردگی) کلوپیدوگرل سیکلوفسفامید (عوامل آلکیله‌کننده) افاویرنز (مهارکننده‌های ترانس کریپتاز معکوس) ایفوسفامید (عوامل آلکیله‌کننده) کتامین (منفک کننده) متادون (opiate replacement therapy) methoxetamine (عامل منفک کننده، آنتاگونیست NMDA) نویراپین (مهارکننده‌های ترانس کریپتاز معکوس) پروپوفول (بیهوش‌کننده) سلژیلین سرترالین (داروهای ضدافسردگی) سورافنیب (مهارکننده پروتئین کیناز) تاموکسیفن (SERM) والپروات (داروی ضد تشنج) وراپامیل (بسترهای حساس جزئی/متوسط)	قوی: اورفنادرین (آنتی‌کولینرژیک) متوسط: سلژیلین قدرت نامشخص chlorpyrifos (حشره‌کش) کلوپیدوگرل (داروهای ضد پلاکت) کلوتریمازول (ضد قارچ) کورکومین (مکمل غذایی) (موجود در زردچوبه) اتینیل‌استرادیول (estrogen, ضد بارداری) فلوکستین (داروهای ضدافسردگی) فلووکسامین (داروهای ضدافسردگی) ایتراکونازول (ضد قارچ) کتوکونازول (ضد قارچ) ممانتین (آنتاگونیست NMDA) پاروکستین (داروهای ضدافسردگی) رالوکسیفن (SERM) سرترالین (داروهای ضدافسردگی) تیوتپا (anticancer) تیکلوپیدین (داروهای ضد پلاکت)	کاربامازپین (داروی ضد تشنج، داروهای تثبیت‌کننده خلق) فنوباربیتال (داروی ضد تشنج) فنی‌توئین (داروی ضد تشنج) ریفامپین (باکتری‌کش) افاویرنز (ویروس)

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000030483 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: cytochrome P450".
↑ Swedish environmental classification of pharmaceuticals - دارونامه - Facts for prescribers (Fakta för förskrivare). Retrieved July 2011
↑ Flockhart DA (2007). "Drug Interactions: Cytochrome P₄₅₀ Drug Interaction Table". Indiana University School of Medicine. Retrieved on December 25, 2008.
↑ Alkattan, A. , & Alsalameen, E. (2021). Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment. Expert opinion on drug metabolism & toxicology, 10.1080/17425255.2021.1925249. Advance online publication. https://doi.org/10.1080/17425255.2021.1925249
↑ Rao LK, Flaker AM, Friedel CC, Kharasch ED (December 2016). "Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance". Anesthesiology. 125 (6): 1103–1112. doi:10.1097/ALN.0000000000001392. PMID 27763887. S2CID 41380105.
↑ Meyer MR, Bach M, Welter J, Bovens M, Turcant A, Maurer HH (July 2013). "Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn". Analytical and Bioanalytical Chemistry. 405 (19): 6307–21. doi:10.1007/s00216-013-7051-6. PMID 23774830. S2CID 27966043.
↑ Walsky RL, Astuccio AV, Obach RS (December 2006). "Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6". Journal of Clinical Pharmacology. 46 (12): 1426–38. doi:10.1177/0091270006293753. PMID 17101742. S2CID 40915941.
↑ Obach RS, Cox LM, Tremaine LM (February 2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metabolism and Disposition. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048. S2CID 7254643.
↑ Ekins S, Iyer M, Krasowski MD, Kharasch ED (June 2008). "Molecular characterization of CYP2B6 substrates". Current Drug Metabolism. 9 (5): 363–73. doi:10.2174/138920008784746346. PMC 2426921. PMID 18537573.
↑ Phillips BG, Gandhi AJ, Sanoski CA, Just VL, Bauman JL (1997). "Comparison of intravenous diltiazem and verapamil for the acute treatment of atrial fibrillation and atrial flutter". Pharmacotherapy. 17 (6): 1238–45. PMID 9399606.
↑ Guo Z, Raeissi S, White RB, Stevens JC (March 1997). "Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes". Drug Metabolism and Disposition. 25 (3): 390–3. PMID 9172960.
↑ Sridar, C.; Kenaan, C.; Hollenberg, P. F. (2012). "Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts". Drug Metabolism and Disposition: The Biological Fate of Chemicals. 40 (12): 2256–2266. doi:10.1124/dmd.112.046979. PMC 3500550. PMID 22936314.
↑ Volak LP, Ghirmai S, Cashman JR, Court MH (August 2008). "Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor". Drug Metabolism and Disposition. 36 (8): 1594–605. doi:10.1124/dmd.108.020552. PMC 2574793. PMID 18480186.
↑ Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP (June 2007). "Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products". Toxicology. 235 (1–2): 83–91. doi:10.1016/j.tox.2007.03.007. PMID 17433521.
↑ Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ (October 2000). "CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants". Drug Metabolism and Disposition. 28 (10): 1176–83. PMID 10997936.
↑ Makino KM, Porsteinsson AP (June 2011). "Memantine: a treatment for Alzheimer's disease with a new formulation". Aging Health. 7 (3): 349–62. doi:10.2217/ahe.11.31.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000030483 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: cytochrome P450".

[FASS-5] Swedish environmental classification of pharmaceuticals - دارونامه - Facts for prescribers (Fakta för förskrivare). Retrieved July 2011

[Flockhart-6] Flockhart DA (2007). "Drug Interactions: Cytochrome P₄₅₀ Drug Interaction Table". Indiana University School of Medicine. Retrieved on December 25, 2008.

[7] Alkattan, A. , & Alsalameen, E. (2021). Polymorphisms of genes related to phase-I metabolic enzymes affecting the clinical efficacy and safety of clopidogrel treatment. Expert opinion on drug metabolism & toxicology, 10.1080/17425255.2021.1925249. Advance online publication. https://doi.org/10.1080/17425255.2021.1925249

[pmid_27763887-8] Rao LK, Flaker AM, Friedel CC, Kharasch ED (December 2016). "Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance". Anesthesiology. 125 (6): 1103–1112. doi:10.1097/ALN.0000000000001392. PMID 27763887. S2CID 41380105.

[pmid_23774830-9] Meyer MR, Bach M, Welter J, Bovens M, Turcant A, Maurer HH (July 2013). "Ketamine-derived designer drug methoxetamine: metabolism including isoenzyme kinetics and toxicological detectability using GC-MS and LC-(HR-)MSn". Analytical and Bioanalytical Chemistry. 405 (19): 6307–21. doi:10.1007/s00216-013-7051-6. PMID 23774830. S2CID 27966043.

[pmid_17101742-10] Walsky RL, Astuccio AV, Obach RS (December 2006). "Evaluation of 227 drugs for in vitro inhibition of cytochrome P450 2B6". Journal of Clinical Pharmacology. 46 (12): 1426–38. doi:10.1177/0091270006293753. PMID 17101742. S2CID 40915941.

[pmid_15547048-11] Obach RS, Cox LM, Tremaine LM (February 2005). "Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study". Drug Metabolism and Disposition. 33 (2): 262–70. doi:10.1124/dmd.104.002428. PMID 15547048. S2CID 7254643.

[Ekins_Iyer_Krasowski_Kharasch_2008_pp._363–73-12] Ekins S, Iyer M, Krasowski MD, Kharasch ED (June 2008). "Molecular characterization of CYP2B6 substrates". Current Drug Metabolism. 9 (5): 363–73. doi:10.2174/138920008784746346. PMC 2426921. PMID 18537573.

[BG_Al._1997-13] Phillips BG, Gandhi AJ, Sanoski CA, Just VL, Bauman JL (1997). "Comparison of intravenous diltiazem and verapamil for the acute treatment of atrial fibrillation and atrial flutter". Pharmacotherapy. 17 (6): 1238–45. PMID 9399606.

[pmid_9172960-14] Guo Z, Raeissi S, White RB, Stevens JC (March 1997). "Orphenadrine and methimazole inhibit multiple cytochrome P450 enzymes in human liver microsomes". Drug Metabolism and Disposition. 25 (3): 390–3. PMID 9172960.

[Sridar-15] Sridar, C.; Kenaan, C.; Hollenberg, P. F. (2012). "Inhibition of Bupropion Metabolism by Selegiline: Mechanism-Based Inactivation of Human CYP2B6 and Characterization of Glutathione and Peptide Adducts". Drug Metabolism and Disposition: The Biological Fate of Chemicals. 40 (12): 2256–2266. doi:10.1124/dmd.112.046979. PMC 3500550. PMID 22936314.

[pmid_18480186-16] Volak LP, Ghirmai S, Cashman JR, Court MH (August 2008). "Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor". Drug Metabolism and Disposition. 36 (8): 1594–605. doi:10.1124/dmd.108.020552. PMC 2574793. PMID 18480186.

[pmid_17433521-17] Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP (June 2007). "Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products". Toxicology. 235 (1–2): 83–91. doi:10.1016/j.tox.2007.03.007. PMID 17433521.

[pmid_10997936-18] Hesse LM, Venkatakrishnan K, Court MH, von Moltke LL, Duan SX, Shader RI, Greenblatt DJ (October 2000). "CYP2B6 mediates the in vitro hydroxylation of bupropion: potential drug interactions with other antidepressants". Drug Metabolism and Disposition. 28 (10): 1176–83. PMID 10997936.

[19] Makino KM, Porsteinsson AP (June 2011). "Memantine: a treatment for Alzheimer's disease with a new formulation". Aging Health. 7 (3): 349–62. doi:10.2217/ahe.11.31.