MAP1LC3B

MAP1LC3B
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1V49, 2LUE, 2ZJD, 3VTU, 3VTV, 3VTW, 3WAO, 3X0W, 4WAA, 5D94, 5DCN
معین‌کننده‌ها
نام‌های دیگر	MAP1LC3B, ATG8F, LC3B, MAP1A/1BLC3, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta
شناسه‌های بیرونی	OMIM: 609604 MGI: 1914693 HomoloGene: 69359 GeneCards: MAP1LC3B
موقعیت ژن (موش)
کروموزوم	کروموزوم ۸ (موش)
پایان	122,325,499 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001948، GO:0016582 پیوند پروتئینی; • ubiquitin protein ligase binding; • microtubule binding;
ترکیبات سلولی	• سیتوپلاسم; • organelle membrane; • membrane; • intracellular anatomical structure; • میتوکندری; • GO:0035085 ساقه مژکی; • ریزلوله; • اسکلت سلولی; • GO:0016023 cytoplasmic vesicle; • دستگاه غشایی درونی; • autophagosome membrane; • سیتوزول; • autophagosome; • autolysosome;
فرایند زیستی	• میتوفاژی; • autophagosome assembly; • خودخواری; • cellular response to nitrogen starvation; • cellular response to starvation; • macroautophagy; • GO:0000046 autophagosome maturation; • positive regulation of mucus secretion;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	81631
	67443
	ENSG00000140941
	ENSMUSG00000031812
	Q9GZQ8
	Q9CQV6
	NM_022818
	NM_001364358 NM_026160، NM_001364358
	NP_073729
	NP_001351287 NP_080436، NP_001351287
	مشاهده/ویرایش موش

زنجیرهٔ سبک ۳بی پروتئین‌های 1A/1B مرتبط با ریزلوله (انگلیسی: Microtubule-associated proteins 1A/1B light chain 3B) یک پروتئین است که در انسان توسط ژن «MAP1LC3B» کُدگذاری می‌شود. این پروتئین مقش حیاتی در پدیدهٔ خودخواری دارد و پرکاربردترین نشانگر زیستی اتوفاگوزوم است. این پروتئین نخستین بار در ریزلوله‌های مغز موش صحرایی کشف شد.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000031812 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MAP1LC3B microtubule-associated protein 1 light chain 3 beta".
↑ Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al. (Jan 2016). "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy. 12 (1): 1–222. doi:10.1080/15548627.2015.1100356. PMC 4835977. PMID 26799652.
↑ Mann SS, Hammarback JA (April 1994). "Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B". The Journal of Biological Chemistry. 269 (15): 11492–7. doi:10.1016/S0021-9258(19)78150-2. PMID 7908909.

پیوند به بیرون

خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q9GZQ8 (Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)) در PDBe-KB.

برای مطالعهٔ بیشتر

Kraft LJ, Kenworthy AK (January 2012). "Imaging protein complex formation in the autophagy pathway: analysis of the interaction of LC3 and Atg4B(C74A) in live cells using Förster resonance energy transfer and fluorescence recovery after photobleaching". Journal of Biomedical Optics. 17 (1): 011008–011008–13. Bibcode:2012JBO....17a1008K. doi:10.1117/1.JBO.17.1.011008. PMC 3380812. PMID 22352642.
Behrends C, Sowa ME, Gygi SP, Harper JW (July 2010). "Network organization of the human autophagy system". Nature. 466 (7302): 68–76. Bibcode:2010Natur.466...68B. doi:10.1038/nature09204. PMC 2901998. PMID 20562859.
Tanida I, Ueno T, Kominami E (December 2004). "LC3 conjugation system in mammalian autophagy". The International Journal of Biochemistry & Cell Biology. 36 (12): 2503–18. doi:10.1016/j.biocel.2004.05.009. PMC 7129593. PMID 15325588.
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y, Yoshimori T (November 2000). "LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing". The EMBO Journal. 19 (21): 5720–8. doi:10.1093/emboj/19.21.5720. PMC 305793. PMID 11060023.
Tanida I, Tanida-Miyake E, Komatsu M, Ueno T, Kominami E (April 2002). "Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p". The Journal of Biological Chemistry. 277 (16): 13739–44. doi:10.1074/jbc.M200385200. PMID 11825910.
Tanida I, Tanida-Miyake E, Nishitani T, Komatsu M, Yamazaki H, Ueno T, Kominami E (March 2002). "Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs". Biochemical and Biophysical Research Communications. 292 (1): 256–62. doi:10.1006/bbrc.2002.6645. PMID 11890701.
He H, Dang Y, Dai F, Guo Z, Wu J, She X, Pei Y, Chen Y, Ling W, Wu C, Zhao S, Liu JO, Yu L (August 2003). "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B". The Journal of Biological Chemistry. 278 (31): 29278–87. doi:10.1074/jbc.M303800200. PMID 12740394.
Tanida I, Sou YS, Ezaki J, Minematsu-Ikeguchi N, Ueno T, Kominami E (August 2004). "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates". The Journal of Biological Chemistry. 279 (35): 36268–76. doi:10.1074/jbc.M401461200. PMID 15187094.
Tanida I, Ueno T, Kominami E (November 2004). "Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes". The Journal of Biological Chemistry. 279 (46): 47704–10. doi:10.1074/jbc.M407016200. PMID 15355958.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000031812 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: MAP1LC3B microtubule-associated protein 1 light chain 3 beta".

[Klionsky_2016-5] Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, et al. (Jan 2016). "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy. 12 (1): 1–222. doi:10.1080/15548627.2015.1100356. PMC 4835977. PMID 26799652.

[6] Mann SS, Hammarback JA (April 1994). "Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B". The Journal of Biological Chemistry. 269 (15): 11492–7. doi:10.1016/S0021-9258(19)78150-2. PMID 7908909.