گیرنده ۲ هورمون آزادکننده کورتیکوتروپین

CRHR2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	3N93, 3N95, 3N96
معین‌کننده‌ها
نام‌های دیگر	CRHR2, CRF-RB, CRF2, CRFR2, HM-CRF, corticotropin releasing hormone receptor 2
شناسه‌های بیرونی	OMIM: 602034 MGI: 894312 HomoloGene: 55612 GeneCards: CRHR2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	55,110,001 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• G protein-coupled receptor activity; • signal transducer activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • corticotrophin-releasing factor receptor activity; • transmembrane signaling receptor activity; • peptide hormone binding; • corticotropin-releasing hormone receptor activity;
ترکیبات سلولی	• integral component of membrane; • membrane; • پوسته یاخته; • integral component of plasma membrane; • آسه; • دندریت; • axon terminus;
فرایند زیستی	• adenylate cyclase-modulating G protein-coupled receptor signaling pathway; • cell surface receptor signaling pathway; • GO:0072468 ورارسانی پیام; • cellular response to corticotropin-releasing hormone stimulus; • G protein-coupled receptor signaling pathway; • hormone-mediated signaling pathway; • long-term potentiation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1395
	12922
	ENSG00000106113
	ENSMUSG00000003476
	Q13324
	Q60748
	NM_001202481، NM_001202482، NM_001202483، NM_001883، XM_047419892، XM_047419893 NM_001202475، NM_001202481، NM_001202482، NM_001202483، NM_001883، XM_047419892، XM_047419893
	NM_001288619، NM_001288620، NM_009953، XM_006505482 NM_001288618، NM_001288619، NM_001288620، NM_009953، XM_006505482
	NP_001189410، NP_001189411، NP_001189412، NP_001874، XP_016867241، XP_024302433 NP_001189404، NP_001189410، NP_001189411، NP_001189412، NP_001874، XP_016867241، XP_024302433
	NP_001275548، NP_001275549، NP_034083، XP_006505545 NP_001275547، NP_001275548، NP_001275549، NP_034083، XP_006505545
	مشاهده/ویرایش موش

گیرنده ۲ هورمون آزادکننده کورتیکوتروپین (انگلیسی: Corticotropin-releasing hormone receptor 2) که با نام CRF₂ هم شناخته می‌شود؛ یک پروتئین است که در انسان توسط ژن «CRHR2» کُدگذاری می‌شود.

این گیرنده به هورمون آزادکننده کورتیکوتروپین متصل می‌شود و در مغز بیان می‌گردد.

جستارهای وابسته

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000003476 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CRHR2 corticotropin releasing hormone receptor 2".

برای مطالعهٔ بیشتر

Perrin MH, Donaldson CJ, Chen R, Lewis KA, Vale WW (Dec 1993). "Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor". Endocrinology. 133 (6): 3058–61. doi:10.1210/en.133.6.3058. PMID 8243338.
Liaw CW, Lovenberg TW, Barry G, Oltersdorf T, Grigoriadis DE, de Souza EB (Jan 1996). "Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid". Endocrinology. 137 (1): 72–7. doi:10.1210/en.137.1.72. PMID 8536644.
Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW (May 1996). "Cloning and characterization of human urocortin". Endocrinology. 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563.
Meyer AH, Ullmer C, Schmuck K, Morel C, Wishart W, Lübbert H, Engels P (Feb 1997). "Localization of the human CRF2 receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis". Genomics. 40 (1): 189–90. doi:10.1006/geno.1996.4521. PMID 9070940.
Valdenaire O, Giller T, Breu V, Gottowik J, Kilpatrick G (May 1997). "A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor". Biochimica et Biophysica Acta. 1352 (2): 129–32. doi:10.1016/s0167-4781(97)00047-x. PMID 9199241.
Gottowik J, Goetschy V, Henriot S, Kitas E, Fluhman B, Clerc RG, Moreau JL, Monsma FJ, Kilpatrick GJ (Oct 1997). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin". Neuropharmacology. 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. PMID 9423932.
Kostich WA, Chen A, Sperle K, Largent BL (Aug 1998). "Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor". Molecular Endocrinology. 12 (8): 1077–85. doi:10.1210/me.12.8.1077. PMID 9717834.
Willenberg HS, Bornstein SR, Hiroi N, Päth G, Goretzki PE, Scherbaum WA, Chrousos GP (Mar 2000). "Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function". Molecular Psychiatry. 5 (2): 137–41. doi:10.1038/sj.mp.4000720. PMID 10822340.
Reyes TM, Lewis K, Perrin MH, Kunitake KS, Vaughan J, Arias CA, Hogenesch JB, Gulyas J, Rivier J, Vale WW, Sawchenko PE (Feb 2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (5): 2843–8. doi:10.1073/pnas.051626398. PMC 30227. PMID 11226328.
Hsu SY, Hsueh AJ (May 2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor". Nature Medicine. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063.
Lewis K, Li C, Perrin MH, Blount A, Kunitake K, Donaldson C, Vaughan J, Reyes TM, Gulyas J, Fischer W, Bilezikjian L, Rivier J, Sawchenko PE, Vale WW (Jun 2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224.
Wetzka B, Sehringer B, Schäfer WR, Biller S, Hör C, Benedek E, Deppert WR, Zahradnik HP (May 2003). "Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term". Experimental and Clinical Endocrinology & Diabetes. 111 (3): 154–61. doi:10.1055/s-2003-39778. PMID 12784189.
Karteris E, Hillhouse EW, Grammatopoulos D (Feb 2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility". Endocrinology. 145 (2): 890–900. doi:10.1210/en.2003-1210. PMID 14592950.
Seres J, Bornstein SR, Seres P, Willenberg HS, Schulte KM, Scherbaum WA, Ehrhart-Bornstein M (Feb 2004). "Corticotropin-releasing hormone system in human adipose tissue". The Journal of Clinical Endocrinology and Metabolism. 89 (2): 965–70. doi:10.1210/jc.2003-031299. PMID 14764822.
Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Nanda SA, Roseboom PH, Nash GA, Speers JM, Kalin NH (Dec 2004). "Characterization of the human corticotropin-releasing factor2(a) receptor promoter: regulation by glucocorticoids and the cyclic adenosine 5'-monophosphate pathway". Endocrinology. 145 (12): 5605–15. doi:10.1210/en.2004-0907. PMID 15331578.
"Corticotropin-releasing Factor Receptors: CRF₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

پیوند به بیرون

Receptors, Corticotropin-Releasing Hormone در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000003476 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: CRHR2 corticotropin releasing hormone receptor 2".