لسیتین-کلسترول اسیل‌ترانسفراز

LCAT
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	4X96, 4XWG, 4XX1, 5BV7
معین‌کننده‌ها
نام‌های دیگر	LCAT, entrez:3931, lecithin-cholesterol acyltransferase
شناسه‌های بیرونی	OMIM: 606967 MGI: 96755 HomoloGene: 68042 GeneCards: LCAT
موقعیت ژن (موش)
کروموزوم	کروموزوم ۸ (موش)
پایان	106,670,014 bp
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • O-acyltransferase activity; • apolipoprotein A-I binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • acyltransferase activity; • phosphatidylcholine-sterol O-acyltransferase activity;
ترکیبات سلولی	• extracellular region; • high-density lipoprotein particle; • extracellular exosome; • extracellular space;
فرایند زیستی	• steroid metabolic process; • regulation of high-density lipoprotein particle assembly; • سوخت‌وساز لیپید; • cholesterol transport; • cholesterol metabolic process; • cholesterol esterification; • very-low-density lipoprotein particle remodeling; • phospholipid metabolic process; • lipoprotein biosynthetic process; • cholesterol homeostasis; • phosphatidylcholine biosynthetic process; • phosphatidylcholine metabolic process; • reverse cholesterol transport; • high-density lipoprotein particle remodeling;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3931
	16816
	ENSG00000213398
	ENSMUSG00000035237
	P04180
	P16301
	NM_000229
	NM_008490
	NP_000220
	NP_032516
	مشاهده/ویرایش موش

لسیتین-کلسترول اسیل‌ترانسفراز (انگلیسی: Lecithin–cholesterol acyltransferase) که با نام اختصاری LCAT هم شناخته می‌شود، یک آنزیم است که کلسترول را به کلستریل استر (یک نوع کلسترول آب‌گریز) مبدل می‌کند که در هستهٔ یک ذرهٔ لیپوپروتئینی گرد هم آمده و در نهایت یک کرهٔ لیپوپروتئین پرچگالی ایجاد می‌کند و واکنش شیمیایی را بالاجبار یک‌طرفه می‌کند. این آنزیم در پلاسمای خون به لیپوپروتئین پرچگالی (آلفا-ال‌سی‌ای‌تی) و لیپوپروتئین کم‌چگالی (بتا-ال‌سی‌ای‌تی) متصل است. کمبود این آنزیم به دلیل کدر کردن قرنیه توسط کلسترول سبب اختلالات بینایی گشته و همچنین کم‌خونی و آسیب به کلیه‌ها را به‌دنبال دارد.

نقشهٔ هم‌کنشی مسیرهای شیمیایی

با کلیک کردن بر روی نام ژن‌ها و پروتئین‌ها در نقشهٔ زیر، به مقالهٔ مربوط هدایت خواهید شد. Click on genes, proteins and metabolites below to link to respective articles.

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مسیر استاتین edit

↑ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000035237 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Lecithin-Cholesterol Acyltransferase Deficiency: Overview, Presentation, Differential Diagnosis". 2016-08-08.
↑ Reference, Genetics Home. "LCAT gene". Genetics Home Reference. Retrieved 2016-12-11.

برای مطالعهٔ بیشتر

Dobiásová M, Frohlich J (1999). "Advances in understanding of the role of lecithin cholesterol acyltransferase (LCAT) in cholesterol transport". Clin Chim Acta. 286 (1–2): 257–71. doi:10.1016/S0009-8981(99)00106-0. PMID 10511297.
Kuivenhoven JA, Pritchard H, Hill J, et al. (1997). "The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes". J. Lipid Res. 38 (2): 191–205. PMID 9162740.
de Vries R, Borggreve SE, Dullaart RP (2004). "Role of lipases, lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in abnormal high density lipoprotein metabolism in insulin resistance and type 2 diabetes mellitus". Clin. Lab. 49 (11–12): 601–13. PMID 14651331.
Teisberg P, Gjone E, Olaisen B (1975). "Genetics of LCAT (lecithin: cholesterol acyltransferase) deficiency". Ann. Hum. Genet. 38 (3): 327–31. doi:10.1111/j.1469-1809.1975.tb00617.x. PMID 806250. S2CID 42785012.
Cogan DG, Kruth HS, Datilis MB, Martin N (1993). "Corneal opacity in LCAT disease". Cornea. 11 (6): 595–9. doi:10.1097/00003226-199211000-00021. PMID 1468226.
Skretting G, Blomhoff JP, Solheim J, Prydz H (1992). "The genetic defect of the original Norwegian lecithin:cholesterol acyltransferase deficiency families". FEBS Lett. 309 (3): 307–10. doi:10.1016/0014-5793(92)80795-I. PMID 1516702. S2CID 26714265.
Skretting G, Prydz H (1992). "An amino acid exchange in exon I of the human lecithin: cholesterol acyltransferase (LCAT) gene is associated with fish eye disease". Biochem. Biophys. Res. Commun. 182 (2): 583–7. doi:10.1016/0006-291X(92)91772-I. PMID 1571050.
Furukawa Y, Urano T, Hida Y, et al. (1992). "Interaction of rat lecithin-cholesterol acyltransferase with rat apolipoprotein A-I and with lecithin-cholesterol vesicles". J. Biochem. 111 (3): 413–8. doi:10.1093/oxfordjournals.jbchem.a123771. PMID 1587806.
Minnich A, Collet X, Roghani A, et al. (1992). "Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding". J. Biol. Chem. 267 (23): 16553–60. PMID 1644835.
Bujo H, Kusunoki J, Ogasawara M, et al. (1992). "Molecular defect in familial lecithin:cholesterol acyltransferase (LCAT) deficiency: a single nucleotide insertion in LCAT gene causes a complete deficient type of the disease". Biochem. Biophys. Res. Commun. 181 (3): 933–40. doi:10.1016/0006-291X(91)92026-G. PMID 1662503.
Gotoda T, Yamada N, Murase T, et al. (1991). "Differential phenotypic expression by three mutant alleles in familial lecithin:cholesterol acyltransferase deficiency". Lancet. 338 (8770): 778–81. doi:10.1016/0140-6736(91)90665-C. PMID 1681161. S2CID 9708282.
Klein HG, Lohse P, Pritchard PH, et al. (1992). "Two different allelic mutations in the lecithin-cholesterol acyltransferase gene associated with the fish eye syndrome. Lecithin-cholesterol acyltransferase (Thr123----Ile) and lecithin-cholesterol acyltransferase (Thr347----Met)". J. Clin. Invest. 89 (2): 499–506. doi:10.1172/JCI115612. PMC 442879. PMID 1737840.
Maeda E, Naka Y, Matozaki T, et al. (1991). "Lecithin-cholesterol acyltransferase (LCAT) deficiency with a missense mutation in exon 6 of the LCAT gene". Biochem. Biophys. Res. Commun. 178 (2): 460–6. doi:10.1016/0006-291X(91)90129-U. PMID 1859405.
Funke H, von Eckardstein A, Pritchard PH, et al. (1991). "A molecular defect causing fish eye disease: an amino acid exchange in lecithin-cholesterol acyltransferase (LCAT) leads to the selective loss of alpha-LCAT activity". Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4855–9. doi:10.1073/pnas.88.11.4855. PMC 51765. PMID 2052566.
Taramelli R, Pontoglio M, Candiani G, et al. (1990). "Lecithin cholesterol acyl transferase deficiency: molecular analysis of a mutated allele". Hum. Genet. 85 (2): 195–9. doi:10.1007/BF00193195. PMID 2370048. S2CID 23994746.
Rogne S, Skretting G, Larsen F, et al. (1987). "The isolation and characterisation of a cDNA clone for human lecithin:cholesterol acyl transferase and its use to analyse the genes in patients with LCAT deficiency and fish eye disease". Biochem. Biophys. Res. Commun. 148 (1): 161–9. doi:10.1016/0006-291X(87)91090-4. PMID 2823801.
Tata F, Chaves ME, Markham AF, et al. (1987). "The isolation and characterisation of cDNA and genomic clones for human lecithin: cholesterol acyltransferase". Biochim. Biophys. Acta. 910 (2): 142–8. doi:10.1016/0167-4781(87)90066-2. PMID 2823898.
Yang CY, Manoogian D, Pao Q, et al. (1987). "Lecithin:cholesterol acyltransferase. Functional regions and a structural model of the enzyme". J. Biol. Chem. 262 (7): 3086–91. PMID 2880847.
McLean J, Fielding C, Drayna D, et al. (1986). "Cloning and expression of human lecithin-cholesterol acyltransferase cDNA". Proc. Natl. Acad. Sci. U.S.A. 83 (8): 2335–9. doi:10.1073/pnas.83.8.2335. PMC 323291. PMID 3458198.
Azoulay M, Henry I, Tata F, et al. (1987). "The structural gene for lecithin:cholesterol acyl transferase (LCAT) maps to 16q22". Ann. Hum. Genet. 51 (Pt 2): 129–36. doi:10.1111/j.1469-1809.1987.tb01054.x. PMID 3674753. S2CID 31911235.
McLean J, Wion K, Drayna D, et al. (1987). "Human lecithin-cholesterol acyltransferase gene: complete gene sequence and sites of expression". Nucleic Acids Res. 14 (23): 9397–406. doi:10.1093/nar/14.23.9397. PMC 311966. PMID 3797244.

[WikiPathways-6] The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000035237 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Lecithin-Cholesterol Acyltransferase Deficiency: Overview, Presentation, Differential Diagnosis". 2016-08-08.

[5] Reference, Genetics Home. "LCAT gene". Genetics Home Reference. Retrieved 2016-12-11.