N-Myc

MYCN
معین‌کننده‌ها
نام‌های دیگر	MYCN, MODED, N-myc, NMYC, ODED, bHLHe37, v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog, MYCN proto-oncogene, bHLH transcription factor, MYCNsORF, MYCNsPEP
شناسه‌های بیرونی	OMIM: 164840 MGI: 97357 HomoloGene: 3922 GeneCards: MYCN
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۲ (موش)
پایان	12,991,915 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• DNA binding; • protein dimerization activity; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001077، GO:0001212، GO:0001213، GO:0001211، GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • kinase binding; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
ترکیبات سلولی	• کروماتین; • هسته یاخته; • هستک;
فرایند زیستی	• GO:0009373 regulation of transcription, DNA-templated; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • GO:1901313 positive regulation of gene expression; • negative regulation of gene expression; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • transcription by RNA polymerase II; • cartilage condensation; • positive regulation of mesenchymal cell proliferation; • positive regulation of cell population proliferation; • positive regulation of cell death; • lung development; • embryonic digit morphogenesis; • regulation of inner ear auditory receptor cell differentiation; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • embryonic skeletal system morphogenesis; • negative regulation of astrocyte differentiation; • branching morphogenesis of an epithelial tube; • negative regulation of reactive oxygen species metabolic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4613
	18109
	ENSG00000134323
	ENSMUSG00000037169
	P04198
	P03966
	NM_001293228، NM_001293231، NM_001293233، XM_047444434 NM_005378، NM_001293228، NM_001293231، NM_001293233، XM_047444434
	NM_008709
	NP_001280160، NP_001280162، NP_005369 NP_001280157، NP_001280160، NP_001280162، NP_005369
	NP_032735
	مشاهده/ویرایش موش

پروتئین پروتو-آنکوژن N-Myc (انگلیسی: N-myc proto-oncogene protein) یا پروتئین مارپیچ-حلقه-مارپیچ قلیایی ۳۷ که با نام‌های اختصاری «N-Myc» و «bHLHe37» هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «MYCN» کدگذاری می‌شود.

این ژن یکی از اعضای خانوادهٔ MYCN است که گروهی از فاکتورهای رونویسی بوده و یک دومین مارپیچ-حلقه-مارپیچ قلیایی دارند. پروتئین ساخته شده توسط این ژن، در درون هسته جای دارد و به‌منظور اتصال به دی‌ان‌ای، می‌بایست با پروتئین دیگری، یک ساختار دوتایی تشکیل دهند. (دایمریزه شوند). پروتئین N-Myc در مغز جنین در مقادیر زیاد ساخته می‌شود و برای رشد و تکامل طبیعی مغز ضروری است.

تشدید فعالیت یا تولید بیش از حدِ N-Myc سبب بروز تومور می‌شود. مقادیر زیاد این پروتئین با تومورهای گوناگونی به‌ویژه نوروبلاستوما در ارتباط نزدیک است، به نحوی که تشدید و افزایش فعالیت آن با پیش‌اگهی بد نوروبلاستوما مرتبط است.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000037169 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)".
↑ Knoepfler PS, Cheng PF, Eisenman RN (2002). "N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation". Genes Dev. 16 (20): 2699–712. doi:10.1101/gad.1021202. PMC 187459. PMID 12381668.
↑ Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). "Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas". Nat. Genet. 4 (2): 191–4. doi:10.1038/ng0693-191. PMID 8102299.
↑ Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423.
↑ Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage". Science. 224 (4653): 1121–4. doi:10.1126/science.6719137. PMID 6719137.

برای مطالعهٔ بیشتر

Lüscher B (2001). "Function and regulation of the transcription factors of the Myc/Max/Mad network". Gene. 277 (1–2): 1–14. doi:10.1016/S0378-1119(01)00697-7. PMID 11602341.
Hagiwara T, Nakaya K, Nakamura Y, Nakajima H, Nishimura S, Taya Y (1992). "Specific phosphorylation of the acidic central region of the N-myc protein by casein kinase II". Eur. J. Biochem. 209 (3): 945–50. doi:10.1111/j.1432-1033.1992.tb17367.x. PMID 1425701.
Fougerousse F, Meloni R, Roudaut C, Beckmann JS (1992). "Dinucleotide repeat polymorphism at the human hemoglobin alpha-1 pseudo-gene (HBAP1)". Nucleic Acids Res. 20 (5): 1165. doi:10.1093/nar/20.5.1165. PMC 312136. PMID 1549498.
Krystal GW, Armstrong BC, Battey JF (1990). "N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts". Mol. Cell. Biol. 10 (8): 4180–91. PMC 360949. PMID 1695323.
Blackwood EM, Eisenman RN (1991). "Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc". Science. 251 (4998): 1211–7. doi:10.1126/science.2006410. PMID 2006410.
Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423.
Ibson JM, Rabbitts PH (1988). "Sequence of a germ-line N-myc gene and amplification as a mechanism of activation". Oncogene. 2 (4): 399–402. PMID 2834684.
Stanton LW, Schwab M, Bishop JM (1986). "Nucleotide sequence of the human N-myc gene". Proc. Natl. Acad. Sci. U.S.A. 83 (6): 1772–6. doi:10.1073/pnas.83.6.1772. PMC 323166. PMID 2869488.
Michitsch RW, Melera PW (1985). "Nucleotide sequence of the 3' exon of the human N-myc gene". Nucleic Acids Res. 13 (7): 2545–58. doi:10.1093/nar/13.7.2545. PMC 341174. PMID 2987858.
Slamon DJ, Boone TC, Seeger RC, Keith DE, Chazin V, Lee HC, Souza LM (1986). "Identification and characterization of the protein encoded by the human N-myc oncogene". Science. 232 (4751): 768–72. doi:10.1126/science.3008339. PMID 3008339.
Garson JA, van den Berghe JA, Kemshead JT (1987). "Novel non-isotopic in situ hybridization technique detects small (1 Kb) unique sequences in routinely G-banded human chromosomes: fine mapping of N-myc and beta-NGF genes". Nucleic Acids Res. 15 (12): 4761–70. doi:10.1093/nar/15.12.4761. PMC 305916. PMID 3299258.
Stanton LW, Bishop JM (1988). "Alternative processing of RNA transcribed from NMYC". Mol. Cell. Biol. 7 (12): 4266–72. PMC 368108. PMID 3437890.
Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW (1986). "Human N-myc is closely related in organization and nucleotide sequence to c-myc". Nature. 319 (6048): 73–7. doi:10.1038/319073a0. PMID 3510398.
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پیوند به بیرون

MYCN protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000037169 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Entrez Gene: MYCN v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)".

[5] Knoepfler PS, Cheng PF, Eisenman RN (2002). "N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation". Genes Dev. 16 (20): 2699–712. doi:10.1101/gad.1021202. PMC 187459. PMID 12381668.

[pmid8102299-6] Cheng JM, Hiemstra JL, Schneider SS, Naumova A, Cheung NK, Cohn SL, Diller L, Sapienza C, Brodeur GM (June 1993). "Preferential amplification of the paternal allele of the N-myc gene in human neuroblastomas". Nat. Genet. 4 (2): 191–4. doi:10.1038/ng0693-191. PMID 8102299.

[7] Emanuel BS, Balaban G, Boyd JP, Grossman A, Negishi M, Parmiter A, Glick MC (1985). "N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas". Proc. Natl. Acad. Sci. U.S.A. 82 (11): 3736–40. doi:10.1073/pnas.82.11.3736. PMC 397862. PMID 2582423.

[8] Brodeur GM, Seeger RC, Schwab M, Varmus HE, Bishop JM (1984). "Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage". Science. 224 (4653): 1121–4. doi:10.1126/science.6719137. PMID 6719137.