GABARAP

GABARAP
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1GNU, 1KLV, 1KM7, 1KOT, 3D32, 3DOW, 3WIM, 4XC2
معین‌کننده‌ها
نام‌های دیگر	GABARAP, ATG8A, GABARAP-a, MM46, GABA type A receptor-associated protein
شناسه‌های بیرونی	OMIM: 605125 MGI: 1861742 HomoloGene: 134119 GeneCards: GABARAP
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	69,885,777 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• microtubule binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • beta-tubulin binding; • ubiquitin protein ligase binding; • GABA receptor binding;
ترکیبات سلولی	• سیتوپلاسم; • cell body; • دستگاه گلژی; • membrane; • Golgi membrane; • پوسته یاخته; • microtubule associated complex; • smooth endoplasmic reticulum; • autophagosome; • autophagosome membrane; • actin cytoskeleton; • perinuclear region of cytoplasm; • GO:0035085 ساقه مژکی; • کافنده‌تن; • sperm midpiece; • اسکلت سلولی; • ریزلوله; • GO:0016023 cytoplasmic vesicle; • دستگاه غشایی درونی; • سیتوزول;
فرایند زیستی	• chemical synaptic transmission; • protein targeting; • خودخواری; • protein transport; • macroautophagy; • microtubule cytoskeleton organization; • extrinsic apoptotic signaling pathway via death domain receptors; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • GO:0000046 autophagosome maturation; • autophagosome assembly; • میتوفاژی; • cellular response to nitrogen starvation;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	11337
	56486
	ENSG00000170296
	ENSMUSG00000018567
	O95166
	Q9DCD6
	NM_007278
	NM_019749
	NP_009209
	NP_062723
	مشاهده/ویرایش موش

پروتئین مرتبط با گیرندهٔ گاما-آمینوبوتیریک اسید (انگلیسی: Gamma-aminobutyric acid receptor-associated protein) یک پروتئین است که در انسان توسط ژن «GABARAP» کُدگذاری می‌شود.

این پروتئین با مولکول‌های گیرنده ۱ ترانسفرین، ULK1 و GABRG2 تعامل پروتئین-پروتئین دارد.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000018567 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (Jan 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.
↑ Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP" (PDF). FEBS Letters. 518 (1–3): 101–106. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026. S2CID 29391940.
↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
↑ Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research. 85 (1–2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.
↑ Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (Mar 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.
↑ Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (Jan 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. S2CID 14487823.

برای مطالعهٔ بیشتر

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000018567 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9892355-4] Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW (Jan 1999). "GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton". Nature. 397 (6714): 69–72. doi:10.1038/16264. PMID 9892355. S2CID 204990449.

[pmid11997026-5] Green F, O'Hare T, Blackwell A, Enns CA (May 2002). "Association of human transferrin receptor with GABARAP" (PDF). FEBS Letters. 518 (1–3): 101–106. doi:10.1016/S0014-5793(02)02655-8. PMID 11997026. S2CID 29391940.

[pmid17353931-6] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid11146101-7] Okazaki N, Yan J, Yuasa S, Ueno T, Kominami E, Masuho Y, Koga H, Muramatsu M (Dec 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Research. Molecular Brain Research. 85 (1–2): 1–12. doi:10.1016/S0169-328X(00)00218-7. PMID 11146101.

[pmid11948245-8] Nymann-Andersen J, Wang H, Chen L, Kittler JT, Moss SJ, Olsen RW (Mar 2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors". Journal of Neurochemistry. 80 (5): 815–823. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. S2CID 38049055.

[pmid11779480-9] Coyle JE, Qamar S, Rajashankar KR, Nikolov DB (Jan 2002). "Structure of GABARAP in two conformations: implications for GABA(A) receptor localization and tubulin binding". Neuron. 33 (1): 63–74. doi:10.1016/S0896-6273(01)00558-X. PMID 11779480. S2CID 14487823.