ATG12
مولکول ۱۲ مرتبط با خودخواری (انگلیسی: Autophagy related 12) یک پروتئین است که در انسان توسط ژن «ATG12» کُدگذاری میشود.
| ATG12 | |||||||||||||||||||||||||
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| معینکنندهها | |||||||||||||||||||||||||
| نامهای دیگر | ATG12, APG12, APG12L, FBR93, HAPG12, autophagy related 12 | ||||||||||||||||||||||||
| شناسههای بیرونی | OMIM: 609608 MGI: 1914776 HomoloGene: 37953 GeneCards: ATG12 | ||||||||||||||||||||||||
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| همساختشناسی | |||||||||||||||||||||||||
| گونهها | انسان | موش | |||||||||||||||||||||||
| Entrez | |||||||||||||||||||||||||
| آنسامبل | |||||||||||||||||||||||||
| یونیپروت | |||||||||||||||||||||||||
| RefSeq (mRNA) | |||||||||||||||||||||||||
| RefSeq (پروتئین) | |||||||||||||||||||||||||
| موقعیت (UCSC) | ن/م | Chr : 46.86 – 46.87 Mb | |||||||||||||||||||||||
| جستجوی PubMed | |||||||||||||||||||||||||
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برای شروع خودخواری لازم است این مولکول به پروتئین ATG5 از طریق یک سامانهٔ اتصالی شبه یوبیکوتینی، پیوند کووالانسی ایجاد کند. سپس این ترکیب مولکولی دوگانه خودش باعث اتصال پروتئین ATG8 به فسفاتیدیل اتانل آمین میگردد.
این مولکول همچنین در آپوپتوز هم دخالت دارد و اینکار را از طریق تعامل با مولکولهای ضد آپوپتوزی خانواده Bcl-2 انجام میدهد.
منابع
- ↑ GRCm38: Ensembl release 89: ENSMUSG00000032905 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Mizushima N, Sugita H, Yoshimori T, Ohsumi Y (Jan 1999). "A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy". J Biol Chem. 273 (51): 33889–33892. doi:10.1074/jbc.273.51.33889. PMID 9852036.
- ↑ "Entrez Gene: ATG12 ATG12 autophagy related 12 homolog (S. cerevisiae)".
- ↑ J. Geng, and D. J. Klionsky, 'The Atg8 and Atg12 Ubiquitin-Like Conjugation Systems in Macroautophagy. 'Protein Modifications: Beyond the Usual Suspects' Review Series', EMBO Rep, 9 (2008), 859-64.
- ↑ A. D. Rubinstein, M. Eisenstein, Y. Ber, S. Bialik, and A. Kimchi, 'The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis', Mol Cell, 44 (2011), 698-709
برای مطالعهٔ بیشتر
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