AKT2

AKT2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1GZK, 1GZN, 1GZO, 1MRV, 1MRY, 1O6K, 1O6L, 1P6S, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3D0E, 3E87, 3E88, 3E8D
معین‌کننده‌ها
نام‌های دیگر	AKT2, v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2
شناسه‌های بیرونی	OMIM: 164731 MGI: 104874 HomoloGene: 48773 GeneCards: AKT2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۷ (موش)
پایان	27,340,251 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • kinase activity; • protein serine/threonine kinase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • ATP binding; • metal ion binding;
ترکیبات سلولی	• سیتوپلاسم; • اندوزوم; • membrane; • پوسته یاخته; • نوکلئوپلاسم; • ruffle membrane; • cell cortex; • early endosome; • هسته یاخته; • سیتوزول; • intracellular membrane-bounded organelle; • GO:0009327 protein-containing complex; • intracellular anatomical structure;
فرایند زیستی	• positive regulation of protein targeting to membrane; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • positive regulation of fatty acid beta-oxidation; • GO:1901047 insulin receptor signaling pathway; • positive regulation of protein phosphorylation; • GO:0007243 intracellular signal transduction; • regulation of cell migration; • peripheral nervous system myelin maintenance; • positive regulation of glycogen biosynthetic process; • positive regulation of cell motility; • intracellular protein transmembrane transport; • GO:0032861، GO:0032862، GO:0032856 activation of GTPase activity; • فسفرگیری; • positive regulation of glucose metabolic process; • mammary gland epithelial cell differentiation; • multicellular organism development; • protein phosphorylation; • negative regulation of long-chain fatty acid import across plasma membrane; • glycogen biosynthetic process; • positive regulation of vesicle fusion; • GO:0035404 peptidyl-serine phosphorylation; • glucose metabolic process; • cellular response to insulin stimulus; • glycogen metabolic process; • protein localization to plasma membrane; • regulation of translation; • fat cell differentiation; • GO:0072468 ورارسانی پیام; • GO:0006859 carbohydrate transport; • positive regulation of cell migration; • positive regulation of glucose import; • cellular response to high light intensity; • retinal rod cell apoptotic process; • positive regulation of cell population proliferation; • positive regulation of mitochondrial membrane potential; • negative regulation of apoptotic process; • سوخت‌وساز کربوهیدرات; • protein kinase B signaling;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	208
	11652
	ENSG00000105221
	ENSMUSG00000004056
	P31751
	Q60823
	NM_001243027، NM_001243028، NM_001626، XM_011526614، XM_011526615، XM_011526616، XM_011526618، XM_011526619، XM_011526620، XM_017026470، NM_001330511، XM_024451416، XM_024451417 XM_011526622، NM_001243027، NM_001243028، NM_001626، XM_011526614، XM_011526615، XM_011526616، XM_011526618، XM_011526619، XM_011526620، XM_017026470، NM_001330511، XM_024451416، XM_024451417
	NM_007434، XM_006539481، XM_006539482، XM_006539483، NM_001331108، NM_001331109، XM_030241997، XM_030241998، XM_030241999، XM_030242000 NM_001110208، NM_007434، XM_006539481، XM_006539482، XM_006539483، NM_001331108، NM_001331109، XM_030241997، XM_030241998، XM_030241999، XM_030242000
	NP_001229957، NP_001317440، NP_001617، XP_011524916، XP_011524917، XP_011524918، XP_011524920، XP_011524921، XP_011524922، XP_011524924، XP_016881959، XP_024307184، XP_024307185 NP_001229956، NP_001229957، NP_001317440، NP_001617، XP_011524916، XP_011524917، XP_011524918، XP_011524920، XP_011524921، XP_011524922، XP_011524924، XP_016881959، XP_024307184، XP_024307185
	NP_001318037، NP_001318038، NP_031460، XP_006539544، XP_006539545، XP_006539546، XP_030097857، XP_030097858، XP_030097859، XP_030097860 NP_001103678، NP_001318037، NP_001318038، NP_031460، XP_006539544، XP_006539545، XP_006539546، XP_030097857، XP_030097858، XP_030097859، XP_030097860
	مشاهده/ویرایش موش

پروتئین کیناز اختصاصی سرین/ترئونین RAC-بتا (انگلیسی: RAC-beta serine/threonine-protein kinase) یک آنزیم است که در انسان توسط ژن «AKT2» کُدگذاری می‌شود. این پروتئین به عنوان جزئی از مسیر ترارسانی پیام انسولین بر ذخیره‌سازی متابولیت‌ها اثر می‌گذارد.

اهمیت بالینی

بیان بیش از حد این ژن باعث ایجاد نوع تهاجمی تر سرطان لوزالمعده می‌گردد.

موش‌هایی که این پروتئین را ندارند، دچار دیابت شدید می‌شوند و این امر نشان‌دهنده نقش این مولکول در ترارسانی پیام از گیرنده‌های انسولین است. این موش‌ها همچنین در صورت ابتلا به سرطان پستان، پیش‌آگهی بدتری دارند.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000004056 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tsoukas, Michael A.; Mantzoros, Christos S. (2016-01-01), Jameson, J. Larry; De Groot, Leslie J; de Kretser, David M.; Giudice, Linda C. (eds.), "Chapter 37 - Lipodystrophy Syndromes", Endocrinology: Adult and Pediatric (Seventh Edition) (به انگلیسی), Philadelphia: W.B. Saunders, pp. 648–661.e5, doi:10.1016/b978-0-323-18907-1.00037-8, ISBN 978-0-323-18907-1, retrieved 2020-12-18
↑ Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR (November 1992). "AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas". Proc Natl Acad Sci U S A. 89 (19): 9267–71. doi:10.1073/pnas.89.19.9267. PMC 50107. PMID 1409633.
↑ "Entrez Gene: AKT2 v-akt murine thymoma viral oncogene homolog 2".
↑ Heron-Milhavet L, Khouya N, Fernandez A, Lamb NJ (2011). "Akt1 and Akt2: differentiating the aktion". Histol. Histopathol. 26 (5): 651–62. PMID 21432781.

برای مطالعهٔ بیشتر

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پیوند به بیرون

مکان ژنوم AKT2 انسانی و صفحهٔ جزئیات ژنی AKT2 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: P31751 (RAC-beta serine/threonine-protein kinase) در PDBe-KB.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000004056 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-4] Tsoukas, Michael A.; Mantzoros, Christos S. (2016-01-01), Jameson, J. Larry; De Groot, Leslie J; de Kretser, David M.; Giudice, Linda C. (eds.), "Chapter 37 - Lipodystrophy Syndromes", Endocrinology: Adult and Pediatric (Seventh Edition) (به انگلیسی), Philadelphia: W.B. Saunders, pp. 648–661.e5, doi:10.1016/b978-0-323-18907-1.00037-8, ISBN 978-0-323-18907-1, retrieved 2020-12-18

[pmid1409633-5] Cheng JQ, Godwin AK, Bellacosa A, Taguchi T, Franke TF, Hamilton TC, Tsichlis PN, Testa JR (November 1992). "AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas". Proc Natl Acad Sci U S A. 89 (19): 9267–71. doi:10.1073/pnas.89.19.9267. PMC 50107. PMID 1409633.

[entrez-6] "Entrez Gene: AKT2 v-akt murine thymoma viral oncogene homolog 2".

[pmid21432781-7] Heron-Milhavet L, Khouya N, Fernandez A, Lamb NJ (2011). "Akt1 and Akt2: differentiating the aktion". Histol. Histopathol. 26 (5): 651–62. PMID 21432781.