گیرنده پپتید شبه گلوکاگون ۱
گیرنده پپتید شبه گلوکاگون ۱ (انگلیسی: Glucagon-like peptide-1 receptor) یک گیرنده پروتئینی است که در انسان توسط ژن «GLP1R» کُدگذاری میشود و در سلولهای بتای لوزالمعده یافت میشود.
این گیرنده در تنظیم قند خون از طریق افزایش ترشح انسولین دخالت دارد.
این پروتئین یکی از اعضای خانوادهٔ بزرگ «گیرندههای جفتشونده با پروتئین جی» است.
لیراگلوتاید یکی از آگونیستهای این گیرنده است.
منابع
- ↑ GRCm38: Ensembl release 89: ENSMUSG00000024027 - Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Thorens B (September 1992). "Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1". Proc. Natl. Acad. Sci. U.S.A. 89 (18): 8641–5. doi:10.1073/pnas.89.18.8641. PMC 49976. PMID 1326760.
- ↑ Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo-Warren H, Permutt MA, Boyd AE III (October 1993). "Cloning and functional expression of the human glucagon-like peptide-1 (GLP-1) receptor". Endocrinology. 133 (4): 1907–10. doi:10.1210/en.133.4.1907. PMID 8404634.
- ↑ Brubaker PL, Drucker DJ (2002). "Structure-function of the glucagon receptor family of the G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors" (PDF). Recept. Channels. 8 (3–4): 179–88. doi:10.1080/10606820213687. PMID 12529935. Retrieved 2008-07-14.
- ↑ Maguire JJ, Davenport AP. "GLP-1 receptor". IUPHAR/BPS Guide to PHARMACOLOGY. International Union of Basic and Clinical Pharmacology. Retrieved 13 September 2015.
برای مطالعهٔ بیشتر
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پیوند به بیرون
- glucagon-like peptide receptor در سرعنوانهای موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا