گیرنده فاکتور رشد اپیدرمی

EGFR
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2GS2, 2GS6, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0, 4LQM, 4LRM, 4R3P, 4R3R, 4R5S, 4RIW, 4RIX, 4RIY, 4RJ4, 4RJ5, 4RJ6, 4RJ7, 4RJ8, 4TKS, 4WKQ, 4WRG, 4ZJV, 5CNN, 5CNO, 5CAN, 2N5S, 5CAL, 5C8M, 4UV7, 5CAV, 5CZI, 5EDQ, 5CAS, 5CAO, 5CAP, 5EM5, 5HG5, 5EDR, 5EM8, 5EDP, 5HG7, 5CAU, 5C8K, 5C8N, 5CZH, 5CAQ, 5EM6, 4UIP, 5HG9, 5EM7, 5HG8, 4ZSE, 5HIB, 5HIC, 5D41, 4WD5
معین‌کننده‌ها
نام‌های دیگر	EGFR, ERBB, ERBB1, HER1, NISBD2, PIG61, mENA, epidermal growth factor receptor, Genes, erbB-1, ERRP
شناسه‌های بیرونی	OMIM: 131550 MGI: 95294 HomoloGene: 74545 GeneCards: EGFR
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۱ (موش)
پایان	16,868,158 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• kinase activity; • nitric-oxide synthase regulator activity; • transmembrane receptor protein tyrosine kinase activity; • protein phosphatase binding; • ATP binding; • protein kinase activity; • enzyme binding; • MAP kinase kinase kinase activity; • transferase activity; • chromatin binding; • actin filament binding; • double-stranded DNA binding; • transmembrane signaling receptor activity; • nucleotide binding; • signal transducer activity; • identical protein binding; • signaling receptor binding; • protein tyrosine kinase activity; • calmodulin binding; • protein kinase binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • protein heterodimerization activity; • integrin binding; • epidermal growth factor binding; • GO:0008313 epidermal growth factor-activated receptor activity; • ubiquitin protein ligase binding; • cadherin binding; • virus receptor activity; • GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• سیتوپلاسم; • اندوزوم; • multivesicular body, internal vesicle lumen; • پوشش هسته‌ای; • membrane; • focal adhesion; • extracellular region; • perinuclear region of cytoplasm; • هسته یاخته; • cell surface; • شبکه آندوپلاسمی; • integral component of membrane; • دستگاه گلژی; • early endosome membrane; • receptor complex; • پوسته یاخته; • endocytic vesicle; • intracellular anatomical structure; • AP-2 adaptor complex; • endosome membrane; • endoplasmic reticulum membrane; • Golgi membrane; • basolateral plasma membrane; • Shc-EGFR complex; • لیپید رفت; • apical plasma membrane; • سیناپس; • extracellular space; • clathrin-coated vesicle membrane; • integral component of plasma membrane; • basal plasma membrane; • GO:0009327 protein-containing complex;
فرایند زیستی	• positive regulation of protein phosphorylation; • negative regulation of epidermal growth factor receptor signaling pathway; • positive regulation of MAP kinase activity; • protein phosphorylation; • cell surface receptor signaling pathway; • protein insertion into membrane; • cell population proliferation; • morphogenesis of an epithelial fold; • استخوان‌سازی; • GO:1903363 negative regulation of protein catabolic process; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of fibroblast proliferation; • activation of phospholipase C activity; • epidermis development; • learning or memory; • protein autophosphorylation; • positive regulation of phosphorylation; • cerebral cortex cell migration; • digestive tract morphogenesis; • hair follicle development; • فسفرگیری; • positive regulation of epithelial cell proliferation; • embryonic placenta development; • eyelid development in camera-type eye; • GO:0043006 activation of phospholipase A2 activity; • positive regulation of DNA replication; • response to UV-A; • regulation of peptidyl-tyrosine phosphorylation; • positive regulation of cell migration; • positive regulation of nitric oxide biosynthetic process; • cellular response to estradiol stimulus; • GO:1900404 positive regulation of DNA repair; • response to stress; • regulation of nitric-oxide synthase activity; • salivary gland morphogenesis; • MAPK cascade; • cellular response to epidermal growth factor stimulus; • multicellular organism development; • regulation of cell population proliferation; • GO:0000767 cell morphogenesis; • cellular response to amino acid stimulus; • GO:0072468 ورارسانی پیام; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • lung development; • positive regulation of synaptic transmission, glutamatergic; • positive regulation of ERK1 and ERK2 cascade; • phosphatidylinositol phosphate biosynthetic process; • ساعت زیستی; • positive regulation of superoxide anion generation; • positive regulation of cell population proliferation; • positive regulation of vasoconstriction; • response to osmotic stress; • tongue development; • negative regulation of apoptotic process; • response to cobalamin; • liver regeneration; • response to calcium ion; • بهبود زخم; • cellular response to dexamethasone stimulus; • negative regulation of mitotic cell cycle; • cellular response to growth factor stimulus; • hydrogen peroxide metabolic process; • GO:0001306 پاسخ به استرس اکسیداتیو; • response to lipid; • regulation of cell motility; • GO:0007243 intracellular signal transduction; • GO:1904578 response to organic cyclic compound; • magnesium ion homeostasis; • زیست‌ساخت پروتئین; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • positive regulation of smooth muscle cell proliferation; • positive regulation of bone resorption; • midgut development; • positive regulation of inflammatory response; • liver development; • diterpenoid metabolic process; • ERBB2 signaling pathway; • response to estradiol; • positive regulation of cell growth; • positive regulation of prolactin secretion; • astrocyte activation; • cellular response to mechanical stimulus; • response to hydroxyisoflavone; • neuron projection morphogenesis; • ovulation cycle; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • peptidyl-tyrosine phosphorylation; • membrane organization; • positive regulation of protein kinase C activity; • negative regulation of ERBB signaling pathway; • positive regulation of protein localization to plasma membrane; • negative regulation of cardiocyte differentiation; • GO:0072353 cellular response to reactive oxygen species; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • regulation of JNK cascade; • regulation of ERK1 and ERK2 cascade; • cellular response to cadmium ion; • positive regulation of NIK/NF-kappaB signaling; • ورود ویروس; • epidermal growth factor receptor signaling pathway; • positive regulation of peptidyl-serine phosphorylation; • peptidyl-tyrosine autophosphorylation; • cell-cell adhesion; • regulation of phosphatidylinositol 3-kinase signaling; • positive regulation of protein kinase B signaling; • positive regulation of nitric oxide mediated signal transduction; • دگرگونی یاخته‌; • positive regulation of cyclin-dependent protein serine/threonine kinase activity; • negative regulation of Notch signaling pathway; • positive regulation of canonical Wnt signaling pathway; • positive regulation of G1/S transition of mitotic cell cycle;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1956
	13649
	ENSG00000146648
	ENSMUSG00000020122
	P00533
	Q01279
	NM_001346898، NM_001346899، NM_001346900، NM_001346941، NM_005228، NM_201282، NM_201283، NM_201284، XM_047419952، XM_047419953 NM_001346897، NM_001346898، NM_001346899، NM_001346900، NM_001346941، NM_005228، NM_201282، NM_201283، NM_201284، XM_047419952، XM_047419953
	NM_207655، XM_036156288 NM_007912، NM_207655، XM_036156288
	NP_001333827، NP_001333828، NP_001333829، NP_001333870، NP_005219، NP_958439، NP_958440، NP_958441 NP_001333826، NP_001333827، NP_001333828، NP_001333829، NP_001333870، NP_005219، NP_958439، NP_958440، NP_958441
	NP_997538، XP_036012181 NP_031938، NP_997538، XP_036012181
	مشاهده/ویرایش موش

گیرنده فاکتور رشد اپیدرمی (انگلیسی: Epidermal growth factor receptor) که با نام‌های اختصاری دیگری همچون «EGFR", "ErbB-1» و «HER1» هم شناخته می‌شود، یک پروتئین تراپوسته‌ای است که در نقش یک گیرنده برای فاکتور رشد اپیدرمی با لیگاند خارج‌سلولی عمل می‌کند.

این گیرنده یکی از اعضای خانوادهٔ بزرگ «ErbB» و نوعی تیروزین کیناز گیرنده‌ای است. جهش در ژن‌های مسئول این پروتئین‌ها در بروز بسیاری از انواع سرطان‌ها نقش دارد.

فاکتور رشد اپیدرمی و گیرنده‌اش توسط استنلی کوهن در دانشگاه وندربیلت کشف شد. وی به همراه ریتا لوی مونتالچینی در سال ۱۹۸۶ میلادی بابت کشف فاکتور رشد برندهٔ جایزه نوبل فیزیولوژی و پزشکی شدند.

کاهش سیگنالینگ (پیام‌رسانی) در گیرنده فاکتور رشد اپیدرمی و سایر تیروزین کینازهای گیرنده‌ای با بروز برخی بیماری‌ها همچون آلزایمر در ارتباط است. همچنین افزایش سیگنالینگ در این گیرنده‌ها با بروز تعداد فراوانی از سرطان‌ها نقش دارد.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000020122 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Herbst RS (2004). "Review of epidermal growth factor receptor biology". International Journal of Radiation Oncology, Biology, Physics. 59 (2 Suppl): 21–6. doi:10.1016/j.ijrobp.2003.11.041. PMID 15142631.
↑ Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI (August 2007). "ErbB receptors: from oncogenes to targeted cancer treatment". The Journal of Clinical Investigation. 117 (8): 2051–8. doi:10.1172/JCI32278. PMC 1934579. PMID 17671639.

پیوند به بیرون

Epidermal Growth Factor Receptor در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000020122 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15142631-4] Herbst RS (2004). "Review of epidermal growth factor receptor biology". International Journal of Radiation Oncology, Biology, Physics. 59 (2 Suppl): 21–6. doi:10.1016/j.ijrobp.2003.11.041. PMID 15142631.

[pmid17671639-5] Zhang H, Berezov A, Wang Q, Zhang G, Drebin J, Murali R, Greene MI (August 2007). "ErbB receptors: from oncogenes to targeted cancer treatment". The Journal of Clinical Investigation. 117 (8): 2051–8. doi:10.1172/JCI32278. PMC 1934579. PMID 17671639.