پروتئین ۷ ریخت‌زایی استخوان

BMP7
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1BMP, 1LX5, 1LXI, 1M4U
معین‌کننده‌ها
نام‌های دیگر	BMP7, OP-1, bone morphogenetic protein 7
شناسه‌های بیرونی	OMIM: 112267 MGI: 103302 HomoloGene: 20410 GeneCards: BMP7
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	172,782,114 bp
هستی‌شناسی ژن
عملکرد ملکولی	• heparin binding; • cytokine activity; • transforming growth factor beta receptor binding; • growth factor activity; • BMP receptor binding; • GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• extracellular region; • GO:0005578 بافت‌مانه برون‌یاخته‌ای; • extracellular space; • ریزکیسه; • collagen-containing extracellular matrix;
فرایند زیستی	• eye development; • pattern specification process; • skeletal system development; • ureteric bud development; • negative regulation of neuron differentiation; • embryonic pattern specification; • mesenchyme development; • anatomical structure formation involved in morphogenesis; • negative regulation of cell cycle; • mesonephros development; • odontogenesis of dentin-containing tooth; • mesenchymal cell differentiation; • negative regulation of mitotic nuclear division; • animal organ morphogenesis; • metanephric mesenchyme morphogenesis; • metanephros development; • cellular response to hypoxia; • regulation of pathway-restricted SMAD protein phosphorylation; • regulation of removal of superoxide radicals; • steroid hormone mediated signaling pathway; • negative regulation of Notch signaling pathway; • negative regulation of cell population proliferation; • branching involved in salivary gland morphogenesis; • regulation of apoptotic process; • SMAD protein signal transduction; • استخوان‌سازی; • kidney development; • negative regulation of cell death; • tube morphogenesis; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • negative regulation of prostatic bud formation; • cartilage development; • embryonic limb morphogenesis; • مپ کیناز; • embryonic camera-type eye morphogenesis; • positive regulation of neuron differentiation; • positive regulation of cell differentiation; • negative regulation of phosphorylation; • regulation of branching involved in prostate gland morphogenesis; • دگرگونی یاخته‌; • neuron projection morphogenesis; • nephrogenic mesenchyme morphogenesis; • positive regulation of heterotypic cell-cell adhesion; • epithelial cell differentiation; • response to vitamin D; • positive regulation of hyaluranon cable assembly; • positive regulation of bone mineralization; • dendrite development; • negative regulation of neurogenesis; • regulation of phosphorylation; • BMP signaling pathway; • positive regulation of osteoblast differentiation; • گذار اپیتلیال-مزانشیمی; • GO:0045996 negative regulation of transcription, DNA-templated; • negative regulation of NF-kappaB transcription factor activity; • branching morphogenesis of an epithelial tube; • negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis; • negative regulation of glomerular mesangial cell proliferation; • response to estradiol; • monocyte aggregation; • metanephric mesenchymal cell proliferation involved in metanephros development; • positive regulation of cell death; • cell development; • negative regulation of striated muscle cell apoptotic process; • positive regulation of pathway-restricted SMAD protein phosphorylation; • mesoderm formation; • response to peptide hormone; • cellular response to BMP stimulus; • positive regulation of dendrite development; • salivary gland morphogenesis; • هدایت آسه; • multicellular organism development; • positive regulation of peptidyl-threonine phosphorylation; • positive regulation of apoptotic process; • protein localization to nucleus; • embryonic skeletal joint morphogenesis; • camera-type eye morphogenesis; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • endocardial cushion formation; • pericardium morphogenesis; • neural fold elevation formation; • hindbrain development; • cardiac muscle tissue development; • pharyngeal system development; • cardiac septum morphogenesis; • chorio-allantoic fusion; • heart trabecula morphogenesis; • allantois development; • positive regulation of epithelial to mesenchymal transition; • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; • regulation of signaling receptor activity; • GO:1901313 positive regulation of gene expression; • negative regulation of NIK/NF-kappaB signaling; • regulation of MAPK cascade;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	655
	12162
	ENSG00000101144
	ENSMUSG00000008999
	P18075
	P23359
	NM_001719
	NM_007557
	NP_001710; NP_001710.1
	NP_031583
	مشاهده/ویرایش موش

پروتئین ۷ ریخت‌زایی استخوان (انگلیسی: Bone morphogenetic protein 7) که با نام پروتئین ۱ استخوان‌ساز (OP-1) هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «BMP7» کُدگذاری می‌شود.

این پروتئین عضوی از خانوادهٔ فاکتور رشد تغییردهنده بتا است. پروتئین‌های ریخت‌زایی استخوان قادرند رشد و تکامل غضروف و استخوان را تحریک کنند و پروتئین ۷ ریخت‌زایی نیز نقش مهمی در انتقال سلول‌های مزانشیمی به استخوان و غضروف ایفا می‌کند و توسط کوندرین و ناگین مهار می‌شود. ژن «BMP7» که در هم‌ایستایی نیز نقش دارد در مغز، کلیه و مثانه بیان می‌شود.

پروتئین ۷ ریخت‌زایی استخوان سبب القایِ فسفریلاسیون SMAD1 و SMAD5 می‌گردد که به نوبهٔ خود، موجب تحریک رونویسی ژن‌های استخوان‌ساز دیگر می‌گردد.

اهمیت بالینی

پروتئین ۷ ریخت‌زایی استخوان در تکامل کلیهٔ پستانداران نقش دارد و می‌توان از آن در درمان «بیماری مزمن کلیوی» بهره برد. از این پروتئین در ایجاد جوش‌خوردگی مهره‌های کمری و همچنین درمان شکستگی‌های جوش‌نخورده درشت‌نی که انجامِ پیوند استخوان در آنها موفقیت‌آمیز نبوده، استفاده می‌شود. تجویز این پروتئین ممکن است درمان بالقوهٔ ناباروری باشد که پاسخ کافی به مصرف هورمون محرکه فولیکولی نداده‌است.

در آینده ممکن است بتوان از پروتئین ۷ ریخت‌زایی استخوان جهت درمان چاقی در انسان استفاده کرد. این پروتئین نه تنها سبب تولید چربی قهوه‌ای (چربی خوب) می‌شود، بلکه موجب تبدیل چربی‌های روشن یا طلایی، به چربی قهوه‌ای نیز می‌گردد.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000008999 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (November 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
↑ Chen D, Zhao M, Mundy GR (December 2004). "Bone morphogenetic proteins". Growth Factors. 22 (4): 233–41. doi:10.1080/08977190412331279890. PMID 15621726. S2CID 22932278.
↑ Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (August 2001). "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads". The EMBO Journal. 20 (15): 4132–42. doi:10.1093/emboj/20.15.4132. PMC 149146. PMID 11483516.
↑ Zeisberg M, Bottiglio C, Kumar N, Maeshima Y, Strutz F, Müller GA, Kalluri R (December 2003). "Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models". American Journal of Physiology. Renal Physiology. 285 (6): F1060–7. doi:10.1152/ajprenal.00191.2002. PMID 12915382.
↑ Gould SE, Day M, Jones SS, Dorai H (January 2002). "BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells". Kidney International. 61 (1): 51–60. doi:10.1046/j.1523-1755.2002.00103.x. PMID 11786084.
↑ González EA, Lund RJ, Martin KJ, McCartney JE, Tondravi MM, Sampath TK, Hruska KA (April 2002). "Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7". Kidney International. 61 (4): 1322–31. doi:10.1046/j.1523-1755.2002.00258.x. PMID 11918739.
↑ Vaccaro AR, Whang PG, Patel T, Phillips FM, Anderson DG, Albert TJ, Hilibrand AS, Brower RS, Kurd MF, Appannagari A, Patel M, Fischgrund JS (2008). "The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study". The Spine Journal. 8 (3): 457–65. doi:10.1016/j.spinee.2007.03.012. PMID 17588821.
↑ Zimmermann G, Müller U, Löffler C, Wentzensen A, Moghaddam A (November 2007). "[Therapeutic outcome in tibial pseudarthrosis: bone morphogenetic protein 7 (BMP-7) versus autologous bone grafting for tibial fractures]". Der Unfallchirurg (به آلمانی). 110 (11): 931–8. doi:10.1007/s00113-007-1347-y. PMID 17989951.
↑ Shi J, Yoshino O, Osuga Y, Nishii O, Yano T, Taketani Y (March 2010). "Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells". Fertility and Sterility. 93 (4): 1273–9. doi:10.1016/j.fertnstert.2008.11.014. PMID 19108831.
↑ Jha A (2008-08-21). "Obesity: Scientists identify protein that promotes fat-burning". Science. guardian.co.uk. Retrieved 2008-09-03.
↑ Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, et al. (August 2008). "New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure". Nature. 454 (7207): 1000–4. doi:10.1038/nature07221. PMC 2745972. PMID 18719589.
↑ Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, Zhang H, He TC, Kokkotou E, Tseng YH (May 2012). "Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway". FASEB Journal. 26 (5): 2187–96. doi:10.1096/fj.11-199067. PMC 3336788. PMID 22331196.
↑ Okla M, Ha JH, Temel RE, Chung S (February 2015). "BMP7 drives human adipogenic stem cells into metabolically active beige adipocytes". Lipids. 50 (2): 111–20. doi:10.1007/s11745-014-3981-9. PMC 4306630. PMID 25534037.

برای مطالعهٔ بیشتر

Xiao HQ, Shi W, Zhang Y, Liang YZ (April 2009). "[Effect of bone morphogenic protein 7 on nephrin expression and distribution in diabetic rat kidneys]". Nan Fang Yi Ke da Xue Xue Bao = Journal of Southern Medical University. 29 (4): 671–5. PMID 19403392.
Murray LA, Hackett TL, Warner SM, Shaheen F, Argentieri RL, Dudas P, Farrell FX, Knight DA (2008). Eickelberg O (ed.). "BMP-7 does not protect against bleomycin-induced lung or skin fibrosis". PLOS ONE. 3 (12): e4039. doi:10.1371/journal.pone.0004039. PMC 2603595. PMID 19112509.
Freedman BI, Bowden DW, Ziegler JT, Langefeld CD, Lehtinen AB, Rudock ME, Lenchik L, Hruska KA, Register TC, Carr JJ (October 2009). "Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study". Journal of Bone and Mineral Research. 24 (10): 1719–27. doi:10.1359/jbmr.090501. PMC 2743282. PMID 19453255.
Garriock HA, Kraft JB, Shyn SI, Peters EJ, Yokoyama JS, Jenkins GD, Reinalda MS, Slager SL, McGrath PJ, Hamilton SP (January 2010). "A genomewide association study of citalopram response in major depressive disorder". Biological Psychiatry. 67 (2): 133–8. doi:10.1016/j.biopsych.2009.08.029. PMC 2794921. PMID 19846067.
Reddi AH (July 2000). "Bone morphogenetic proteins and skeletal development: the kidney-bone connection". Pediatric Nephrology. 14 (7): 598–601. doi:10.1007/s004670000364. PMID 10912525. S2CID 20757453.
Gautschi OP, Cadosch D, Zellweger R, Joesbury KA, Filgueira L (2009). "Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7". Journal of Musculoskeletal & Neuronal Interactions. 9 (1): 53–60. PMID 19240369.
Alarmo EL, Pärssinen J, Ketolainen JM, Savinainen K, Karhu R, Kallioniemi A (March 2009). "BMP7 influences proliferation, migration, and invasion of breast cancer cells". Cancer Letters. 275 (1): 35–43. doi:10.1016/j.canlet.2008.09.028. PMID 18980801.
Elshaier AM, Hakimiyan AA, Rappoport L, Rueger DC, Chubinskaya S (January 2009). "Effect of interleukin-1beta on osteogenic protein 1-induced signaling in adult human articular chondrocytes". Arthritis and Rheumatism. 60 (1): 143–54. doi:10.1002/art.24151. PMC 2626196. PMID 19116903.
Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM (December 2009). "High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men". Journal of Bone and Mineral Research. 24 (12): 2039–49. doi:10.1359/jbmr.090524. PMC 2791518. PMID 19453261.
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پیوند به بیرون

bone morphogenetic protein 7 در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم BMP7 انسانی و صفحهٔ جزئیات ژنی BMP7 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000008999 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_1427904-4] Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (November 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.

[pmid_15621726-5] Chen D, Zhao M, Mundy GR (December 2004). "Bone morphogenetic proteins". Growth Factors. 22 (4): 233–41. doi:10.1080/08977190412331279890. PMID 15621726. S2CID 22932278.

[pmid_11483516-6] Itoh F, Asao H, Sugamura K, Heldin CH, ten Dijke P, Itoh S (August 2001). "Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads". The EMBO Journal. 20 (15): 4132–42. doi:10.1093/emboj/20.15.4132. PMC 149146. PMID 11483516.

[Zeisberg_2003-7] Zeisberg M, Bottiglio C, Kumar N, Maeshima Y, Strutz F, Müller GA, Kalluri R (December 2003). "Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models". American Journal of Physiology. Renal Physiology. 285 (6): F1060–7. doi:10.1152/ajprenal.00191.2002. PMID 12915382.

[Gould_2002-8] Gould SE, Day M, Jones SS, Dorai H (January 2002). "BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells". Kidney International. 61 (1): 51–60. doi:10.1046/j.1523-1755.2002.00103.x. PMID 11786084.

[pmid_11918739-9] González EA, Lund RJ, Martin KJ, McCartney JE, Tondravi MM, Sampath TK, Hruska KA (April 2002). "Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7". Kidney International. 61 (4): 1322–31. doi:10.1046/j.1523-1755.2002.00258.x. PMID 11918739.

[pmid_17588821-10] Vaccaro AR, Whang PG, Patel T, Phillips FM, Anderson DG, Albert TJ, Hilibrand AS, Brower RS, Kurd MF, Appannagari A, Patel M, Fischgrund JS (2008). "The safety and efficacy of OP-1 (rhBMP-7) as a replacement for iliac crest autograft for posterolateral lumbar arthrodesis: minimum 4-year follow-up of a pilot study". The Spine Journal. 8 (3): 457–65. doi:10.1016/j.spinee.2007.03.012. PMID 17588821.

[pmid_17989951-11] Zimmermann G, Müller U, Löffler C, Wentzensen A, Moghaddam A (November 2007). "[Therapeutic outcome in tibial pseudarthrosis: bone morphogenetic protein 7 (BMP-7) versus autologous bone grafting for tibial fractures]". Der Unfallchirurg (به آلمانی). 110 (11): 931–8. doi:10.1007/s00113-007-1347-y. PMID 17989951.

[pmid_19108831-12] Shi J, Yoshino O, Osuga Y, Nishii O, Yano T, Taketani Y (March 2010). "Bone morphogenetic protein 7 (BMP-7) increases the expression of follicle-stimulating hormone (FSH) receptor in human granulosa cells". Fertility and Sterility. 93 (4): 1273–9. doi:10.1016/j.fertnstert.2008.11.014. PMID 19108831.

[urlObesity:_Scientists_identify_protein_that_promotes_fat-burning_|_Science_|-13] Jha A (2008-08-21). "Obesity: Scientists identify protein that promotes fat-burning". Science. guardian.co.uk. Retrieved 2008-09-03.

[pmid_18719589-14] Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, et al. (August 2008). "New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure". Nature. 454 (7207): 1000–4. doi:10.1038/nature07221. PMC 2745972. PMID 18719589.

[:0-15] Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, Zhang H, He TC, Kokkotou E, Tseng YH (May 2012). "Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway". FASEB Journal. 26 (5): 2187–96. doi:10.1096/fj.11-199067. PMC 3336788. PMID 22331196.

[16] Okla M, Ha JH, Temel RE, Chung S (February 2015). "BMP7 drives human adipogenic stem cells into metabolically active beige adipocytes". Lipids. 50 (2): 111–20. doi:10.1007/s11745-014-3981-9. PMC 4306630. PMID 25534037.