پروتئین ۶ ریخت‌زایی استخوان

BMP6
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2QCW, 2R52, 2R53
معین‌کننده‌ها
نام‌های دیگر	BMP6, VGR, VGR1, bone morphogenetic protein 6
شناسه‌های بیرونی	OMIM: 112266 MGI: 88182 HomoloGene: 1300 GeneCards: BMP6
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• cytokine activity; • BMP receptor binding; • protein heterodimerization activity; • transforming growth factor beta receptor binding; • growth factor activity;
ترکیبات سلولی	• سیتوپلاسم; • extracellular region; • extracellular space; • ریزکیسه;
فرایند زیستی	• eye development; • regulation of apoptotic process; • skeletal system development; • دگرگونی یاخته‌; • cellular response to iron ion; • male genitalia development; • positive regulation of aldosterone secretion; • positive regulation of endothelial cell differentiation; • regulation of MAPK cascade; • positive regulation of endothelial cell proliferation; • SMAD protein signal transduction; • positive regulation of aldosterone biosynthetic process; • response to retinoic acid; • استخوان‌سازی; • kidney development; • positive regulation of bone mineralization; • positive regulation of epithelial cell proliferation; • positive regulation of pathway-restricted SMAD protein phosphorylation; • cellular response to BMP stimulus; • response to magnesium ion; • response to glucocorticoid; • GO:1901227 negative regulation of transcription by RNA polymerase II; • استخوان‌سازی درون‌غضروفی; • response to activity; • BMP signaling pathway; • response to iron ion; • positive regulation of lipopolysaccharide-mediated signaling pathway; • multicellular organismal iron ion homeostasis; • multicellular organism development; • cellular response to mechanical stimulus; • cartilage development; • positive regulation of osteoblast differentiation; • positive regulation of chondrocyte differentiation; • osteoblast differentiation; • GO:0046730، GO:0046737، GO:0046738، GO:0046736 immune response; • positive regulation of neuron differentiation; • positive regulation of protein secretion; • inflammatory response; • type B pancreatic cell development; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of SMAD protein signal transduction; • cellular iron ion homeostasis; • regulation of signaling receptor activity; • positive regulation of cell population proliferation; • cell development;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	654
	12161
	ENSG00000153162
	ن/م
	P22004
	P20722
	NM_001718
	NM_007556
	NP_001709
	NP_031582
	مشاهده/ویرایش موش

پروتئین ۶ ریخت‌زایی استخوان (انگلیسی: Bone morphogenetic protein 6) یک پروتئین است که در انسان توسط ژن «BMP6» کُدگذاری می‌شود.

این پروتئین عضوی از خانوادهٔ فاکتور رشد تغییردهنده بتا است. پروتئین‌های ریخت‌زایی استخوان قادرند رشد و تکامل غضروف و استخوان را تحریک کنند.

پروتئین ۶ ریخت‌زایی استخوان قادر به القای تمامی انواع نشانگرهای استخوان‌ساز در سلول‌های بنیادی مزانشیمی است. این پروتئین همچنین یکی از تنظیم‌کننده‌های مهم هپسیدین است، پپتید کوچکی که توسط کبد ترشح شده و تنظیم‌کنندهٔ اصلی سوخت‌وساز آهن در پستانداران است.

منابع

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Dec 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
↑ Sauermann U, Meyermann R, Schluesener HJ (Jan 1993). "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines". J Neurosci Res. 33 (1): 142–7. doi:10.1002/jnr.490330118. PMID 1453478. S2CID 35064968.
↑ "Entrez Gene: BMP6 bone morphogenetic protein 6".

برای مطالعهٔ بیشتر

Celeste AJ; Iannazzi JA; Taylor RC; et al. (1991). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9843–7. doi:10.1073/pnas.87.24.9843. PMC 55270. PMID 2263636.
Schluesener HJ, Meyermann R (1995). "Immunolocalization of BMP-6, a novel TGF-beta-related cytokine, in normal and atherosclerotic smooth muscle cells". Atherosclerosis. 113 (2): 153–6. doi:10.1016/0021-9150(94)05438-O. PMID 7605353.
Gitelman SE; Kobrin MS; Ye JQ; et al. (1994). "Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo". J. Cell Biol. 126 (6): 1595–609. doi:10.1083/jcb.126.6.1595. PMC 2290953. PMID 8089189.
Barnes J, Anthony CT, Wall N, Steiner MS (1997). "Bone morphogenetic protein-6 expression in normal and malignant prostate". World Journal of Urology. 13 (6): 337–43. doi:10.1007/BF00191214. PMID 9116752. S2CID 31317742.
Hamdy FC; Autzen P; Robinson MC; et al. (1997). "Immunolocalization and messenger RNA expression of bone morphogenetic protein-6 in human benign and malignant prostatic tissue". Cancer Res. 57 (19): 4427–31. PMID 9331107.
Olavesen MG; Bentley E; Mason RV; et al. (1998). "Fine mapping of 39 ESTs on human chromosome 6p23-p25". Genomics. 46 (2): 303–6. doi:10.1006/geno.1997.5032. PMID 9417921.
Rickard DJ; Hofbauer LC; Bonde SK; et al. (1998). "Bone morphogenetic protein-6 production in human osteoblastic cell lines. Selective regulation by estrogen". J. Clin. Invest. 101 (2): 413–22. doi:10.1172/JCI119880. PMC 508581. PMID 9435314.
Tamada H; Kitazawa R; Gohji K; et al. (1998). "Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6)". Biochim. Biophys. Acta. 1395 (3): 247–51. doi:10.1016/S0167-4781(97)00191-7. PMID 9512655.
Ebisawa T; Tada K; Kitajima I; et al. (2000). "Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation". J. Cell Sci. 112 (20): 3519–27. PMID 10504300.
Heikinheimo KA; Laine MA; Ritvos OV; et al. (1999). "Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland". Cancer Res. 59 (22): 5815–21. PMID 10582704.
Ahmed N; Sammons J; Carson RJ; et al. (2001). "Effect of bone morphogenetic protein-6 on haemopoietic stem cells and cytokine production in normal human bone marrow stroma". Cell Biol. Int. 25 (5): 429–35. doi:10.1006/cbir.2000.0662. PMID 11401330. S2CID 85369468.
Shimizu M; Higuchi K; Kasai S; et al. (2003). "A congenic mouse and candidate gene at the Chromosome 13 locus regulating bone density". Mamm. Genome. 13 (7): 335–40. doi:10.1007/s00335-001-2129-4. PMID 12140680. S2CID 23300962.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Moser M; Binder O; Wu Y; et al. (2003). "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation". Mol. Cell. Biol. 23 (16): 5664–79. doi:10.1128/MCB.23.16.5664-5679.2003. PMC 166349. PMID 12897139.
Bobacz K; Gruber R; Soleiman A; et al. (2003). "Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro". Arthritis Rheum. 48 (9): 2501–8. doi:10.1002/art.11248. PMID 13130469.
Lories RJ, Derese I, Ceuppens JL, Luyten FP (2003). "Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis". Arthritis Rheum. 48 (10): 2807–18. doi:10.1002/art.11389. PMID 14558086.
Mungall AJ; Palmer SA; Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Laurikkala J; Kassai Y; Pakkasjärvi L; et al. (2004). "Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot". Dev. Biol. 264 (1): 91–105. doi:10.1016/j.ydbio.2003.08.011. PMID 14623234.

پیوند به بیرون

مکان ژنوم BMP6 انسانی و صفحهٔ جزئیات ژنی BMP6 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[2] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427904-3] Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Dec 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.

[pmid1453478-4] Sauermann U, Meyermann R, Schluesener HJ (Jan 1993). "Cloning of a novel TGF-beta related cytokine, the vgr, from rat brain: cloning of and comparison to homologous human cytokines". J Neurosci Res. 33 (1): 142–7. doi:10.1002/jnr.490330118. PMID 1453478. S2CID 35064968.

[entrez-5] "Entrez Gene: BMP6 bone morphogenetic protein 6".