پروتئین ۵ ریخت‌زایی استخوان

BMP5
معین‌کننده‌ها
نام‌های دیگر	BMP5, entrez:653, bone morphogenetic protein 5
شناسه‌های بیرونی	OMIM: 112265 MGI: 88181 HomoloGene: 22412 GeneCards: BMP5
موقعیت ژن (موش)
کروموزوم	کروموزوم ۹ (موش)
پایان	75,807,592 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• cytokine activity; • BMP receptor binding; • transforming growth factor beta receptor binding; • growth factor activity;
ترکیبات سلولی	• extracellular region; • extracellular space; • ریزکیسه; • cellular component;
فرایند زیستی	• regulation of apoptotic process; • pattern specification process; • skeletal system development; • دگرگونی یاخته‌; • male genitalia development; • regulation of MAPK cascade; • SMAD protein signal transduction; • استخوان‌سازی; • positive regulation of epithelial cell proliferation; • negative regulation of mononuclear cell migration; • negative regulation of cortisol biosynthetic process; • positive regulation of pathway-restricted SMAD protein phosphorylation; • positive regulation of dendrite development; • BMP signaling pathway; • multicellular organism development; • cartilage development; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • negative regulation of insulin-like growth factor receptor signaling pathway; • type B pancreatic cell development; • negative regulation of steroid biosynthetic process; • negative regulation of epithelial to mesenchymal transition; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • negative regulation of cell population proliferation; • negative regulation of aldosterone biosynthetic process; • endocardial cushion formation; • pericardium morphogenesis; • neural fold elevation formation; • hindbrain development; • cardiac muscle tissue development; • pharyngeal system development; • cardiac septum morphogenesis; • chorio-allantoic fusion; • heart trabecula morphogenesis; • allantois development; • regulation of signaling receptor activity; • ear development; • anterior head development; • positive regulation of cell population proliferation; • cell development; • GO:0072468 ورارسانی پیام;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	653
	12160
	ENSG00000112175
	ENSMUSG00000032179
	P22003
	P49003
	NM_021073، NM_001329754، NM_001329756، XM_024446524 XM_011514817، NM_021073، NM_001329754، NM_001329756، XM_024446524
	NM_007555
	NP_001316685، NP_066551، XP_011513119، XP_024302292 NP_001316683، NP_001316685، NP_066551، XP_011513119، XP_024302292; NP_066551.1
	NP_031581
	مشاهده/ویرایش موش

پروتئین ۵ ریخت‌زایی استخوان (انگلیسی: Bone morphogenetic protein 5) یک پروتئین است که در انسان توسط ژن «BMP5» کُدگذاری می‌شود.

این پروتئین عضوی از خانوادهٔ فاکتور رشد تغییردهنده بتا است. پروتئین‌های ریخت‌زایی استخوان قادرند رشد و تکامل غضروف و استخوان را تحریک کنند.

پروتئین ۵ ریخت‌زایی استخوان احتمالاً در بروز برخی انواع سرطان نقش دارد و همچون سایر انواع پروتئین‌های ریخت‌زایی استخوان توسط کوردین و ناگین مهار می‌شود.

این پروتئین به میزان فراوان در سر عصب بینایی (دیسک اُپتیک) وجود دارد و در رشد و تکامل آن نقش دارد. این پروتئین تا حدودی نیز در شش و کبد یافت می‌شود.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000032179 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.
↑ Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience. 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864.
↑ "Entrez Gene: BMP5 bone morphogenetic protein 5".

برای مطالعهٔ بیشتر

Celeste AJ, Iannazzi JA, Taylor RC, Hewick RM, Rosen V, Wang EA, Wozney JM (Dec 1990). "Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone". Proceedings of the National Academy of Sciences of the United States of America. 87 (24): 9843–7. Bibcode:1990PNAS...87.9843C. doi:10.1073/pnas.87.24.9843. PMC 55270. PMID 2263636.
Sakaue M, Kitazawa S, Nishida K, Kitazawa R, Maeda S (Apr 1996). "Molecular cloning and characterization of human bone morphogenic protein (BMP)-5 gene promoter". Biochemical and Biophysical Research Communications. 221 (3): 768–72. doi:10.1006/bbrc.1996.0671. PMID 8630036.
You L, Kruse FE, Pohl J, Völcker HE (Feb 1999). "Bone morphogenetic proteins and growth and differentiation factors in the human cornea". Investigative Ophthalmology & Visual Science. 40 (2): 296–311. PMID 9950587.
Imai N, Iwai A, Hatakeyama S, Matsuzaki K, Kitagawa Y, Kato S, Hokari R, Kawaguchi A, Nagao S, Miyahara T, Itoh K, Miura S (Aug 2001). "Expression of bone morphogenetic proteins in colon carcinoma with heterotopic ossification". Pathology International. 51 (8): 643–8. doi:10.1046/j.1440-1827.2001.01243.x. PMID 11564221. S2CID 35052100.
Jin Y, Lu HB, Liong E, Lau TY, Tipoe GL (Oct 2001). "Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors". Histology and Histopathology. 16 (4): 1013–9. PMID 11642720.
Cohen A, Mulas R, Seri M, Gaiero A, Fichera G, Marini M, Baffico M, Camera G (Jan 2002). "Meier-Gorlin syndrome (ear-patella-short stature syndrome) in an Italian patient: clinical evaluation and analysis of possible candidate genes". American Journal of Medical Genetics. 107 (1): 48–51. doi:10.1002/ajmg.10083. PMID 11807867.
Jiang FX, Stanley EG, Gonez LJ, Harrison LC (Feb 2002). "Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells". Journal of Cell Science. 115 (Pt 4): 753–60. PMID 11865031.
Luo J, Dunn T, Ewing C, Sauvageot J, Chen Y, Trent J, Isaacs W (May 2002). "Gene expression signature of benign prostatic hyperplasia revealed by cDNA microarray analysis". The Prostate. 51 (3): 189–200. doi:10.1002/pros.10087. PMID 11967953. S2CID 42730702.
Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W, Clark AF (Jul 2002). "Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues". Molecular Vision. 8: 241–50. PMID 12131877.
Nakayama N, Han CY, Cam L, Lee JI, Pretorius J, Fisher S, Rosenfeld R, Scully S, Nishinakamura R, Duryea D, Van G, Bolon B, Yokota T, Zhang K (Jan 2004). "A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage". Development. 131 (1): 229–40. doi:10.1242/dev.00901. PMID 14660436.
Xu WP, Shiba H, Mizuno N, Uchida Y, Mouri Y, Kawaguchi H, Kurihara H (2005). "Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells". Cell Biology International. 28 (10): 675–82. doi:10.1016/j.cellbi.2004.06.004. PMID 15516325. S2CID 45261710.
Bobinac D, Marić I, Zoricić S, Spanjol J, Dordević G, Mustać E, Fuckar Z (Jun 2005). "Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer". Croatian Medical Journal. 46 (3): 389–96. PMID 15861517.
Bramlage CP, Häupl T, Kaps C, Ungethüm U, Krenn V, Pruss A, Müller GA, Strutz F, Burmester GR (2006). "Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis". Arthritis Research & Therapy. 8 (3): R58. doi:10.1186/ar1923. PMC 1526630. PMID 16542506.
Wilkins JM, Southam L, Price AJ, Mustafa Z, Carr A, Loughlin J (Mar 2007). "Extreme context specificity in differential allelic expression". Human Molecular Genetics. 16 (5): 537–46. doi:10.1093/hmg/ddl488. PMID 17220169.

پیوند به بیرون

مکان ژنوم BMP5 انسانی و صفحهٔ جزئیات ژنی BMP5 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000032179 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1427904-4] Hahn GV, Cohen RB, Wozney JM, Levitz CL, Shore EM, Zasloff MA, Kaplan FS (Nov 1992). "A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7". Genomics. 14 (3): 759–62. doi:10.1016/S0888-7543(05)80181-8. PMID 1427904.

[pmid11580864-5] Beck HN, Drahushuk K, Jacoby DB, Higgins D, Lein PJ (Mar 2003). "Bone morphogenetic protein-5 (BMP-5) promotes dendritic growth in cultured sympathetic neurons". BMC Neuroscience. 2: 12. doi:10.1186/1471-2202-2-12. PMC 56999. PMID 11580864.

[entrez-6] "Entrez Gene: BMP5 bone morphogenetic protein 5".