پروتئین ۲ ریخت‌زایی استخوان

BMP2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1ES7, 1REU, 1REW, 2GOO, 2H62, 2H64, 2QJ9, 2QJA, 2QJB, 3BK3, 3BMP, 4MID, 4N1D, 4UHY, 4UHZ, 4UI0, 4UI1, 4UI2
معین‌کننده‌ها
نام‌های دیگر	BMP2, BDA2, BMP2A, bone morphogenetic protein 2, SSFSC, SSFSC1
شناسه‌های بیرونی	OMIM: 112261 MGI: 88177 HomoloGene: 926 GeneCards: BMP2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	133,404,805 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• signaling receptor binding; • cytokine activity; • co-receptor binding; • phosphatase activator activity; • growth factor activity; • BMP receptor binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • NAD-retinol dehydrogenase activity; • SMAD binding; • protein heterodimerization activity; • transforming growth factor beta receptor binding;
ترکیبات سلولی	• extracellular region; • cell surface; • BMP receptor complex; • extracellular space; • intracellular membrane-bounded organelle;
فرایند زیستی	• skeletal system development; • positive regulation of Wnt signaling pathway by BMP signaling pathway; • positive regulation of protein phosphorylation; • mesenchyme development; • negative regulation of cell cycle; • odontogenesis of dentin-containing tooth; • telencephalon regionalization; • protein phosphorylation; • atrioventricular valve morphogenesis; • proteoglycan metabolic process; • mesenchymal cell differentiation; • pericardium development; • positive regulation of ERK1 and ERK2 cascade; • BMP signaling pathway involved in heart induction; • animal organ morphogenesis; • inner ear development; • cardiocyte differentiation; • negative regulation of canonical Wnt signaling pathway; • negative regulation of cell population proliferation; • positive regulation of p38MAPK cascade; • pathway-restricted SMAD protein phosphorylation; • cell fate commitment; • GO:0009373 regulation of transcription, DNA-templated; • SMAD protein signal transduction; • استخوان‌سازی; • in utero embryonic development; • mesenchymal cell proliferation involved in ureteric bud development; • regulation of odontogenesis of dentin-containing tooth; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of Wnt signaling pathway; • heart development; • telencephalon development; • branching involved in ureteric bud morphogenesis; • negative regulation of Wnt signaling pathway involved in heart development; • cartilage development; • bone mineralization involved in bone maturation; • positive regulation of cartilage development; • positive regulation of neuron differentiation; • positive regulation of cell differentiation; • thyroid-stimulating hormone-secreting cell differentiation; • inflammatory response; • positive regulation of fat cell differentiation; • negative regulation of steroid biosynthetic process; • positive regulation of MAPK cascade; • Notch signaling pathway; • bone mineralization; • دگرگونی یاخته‌; • chondrocyte differentiation; • corticotropin hormone secreting cell differentiation; • positive regulation of astrocyte differentiation; • positive regulation of bone mineralization; • GO:1904579 cellular response to organic cyclic compound; • positive regulation of ossification; • GO:1901227 negative regulation of transcription by RNA polymerase II; • positive regulation of epithelial to mesenchymal transition; • positive regulation of phosphatase activity; • negative regulation of calcium-independent cell-cell adhesion; • positive regulation of osteoblast differentiation; • protein destabilization; • embryonic heart tube anterior/posterior pattern specification; • osteoblast differentiation; • گذار اپیتلیال-مزانشیمی; • positive regulation of protein binding; • GO:0045996 negative regulation of transcription, DNA-templated; • positive regulation of odontogenesis; • GO:0007329 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; • negative regulation of aldosterone biosynthetic process; • positive regulation of osteoblast proliferation; • response to hypoxia; • positive regulation of endothelial cell proliferation; • positive regulation of cell migration; • negative regulation of cortisol biosynthetic process; • cell-cell signaling; • positive regulation of pathway-restricted SMAD protein phosphorylation; • cellular response to growth factor stimulus; • cellular response to BMP stimulus; • cardiac muscle tissue morphogenesis; • endocardial cushion morphogenesis; • multicellular organism development; • negative regulation of cardiac muscle cell differentiation; • positive regulation of apoptotic process; • negative regulation of insulin-like growth factor receptor signaling pathway; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • cardiac epithelial to mesenchymal transition; • positive regulation of pri-miRNA transcription by RNA polymerase II; • GO:1901313 positive regulation of gene expression; • BMP signaling pathway; • cardiac muscle cell differentiation; • cell development; • regulation of signaling receptor activity; • negative regulation of gene expression; • response to bacterium; • regulation of apoptotic process; • regulation of MAPK cascade;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	650
	12156
	ENSG00000125845
	ENSMUSG00000027358
	P12643
	P21274
	NM_001200
	NM_007553
	NP_001191
	NP_031579
	مشاهده/ویرایش موش

پروتئین ۲ ریخت‌زایی استخوان (انگلیسی: Bone morphogenetic protein 2) یک پروتئین است که در انسان توسط ژن «BMP2» کُدگذاری می‌شود.

این پروتئین عضوی از خانوادهٔ فاکتور رشد تغییردهنده بتا است. پروتئین‌های ریخت‌زایی استخوان قادرند رشد و تکامل غضروف و استخوان را تحریک کنند. این پروتئین در تمایز سلولی استئوبلاست‌ها، تمایز سلول‌های قلبی، تعاملات شیمیایی میان گیرنده‌های سیتوکین و همچنین گذار اپیتلیال-مزانشیمی نقش دارد.

پروتئین ۲ ریخت‌زایی استخوان احتمالاً در ایجاد چربی سفید نقش دارد و اثرات متابولیک دارد.

اهمیت بالینی

پروتئین ۲ ریخت‌زایی استخوان تولید استخوان را تحریک می‌کند. یک نوع نوترکیب از این پروتئین (rhBMP-2) جهت مصارف ارتوپدیک در ایالات متحده آمریکا در دسترس است. کاشت این مادهٔ شیمیایی توسط حامل‌های بیومتریال مختلفی نظیر سرامیک، فلزات، پلیمر و کامپوزیت انجام می‌شود. علاوه بر مصارف ارتوپدی همچون جوش دادن ستون مهره‌ها، این پروتئین نوترکیب در دندان‌پزشکی هم استفاده می‌شود. البته در یک گزارش پژوهشی که در سال ۲۰۱۱ منتشر شد، استفاده از این ماده در جراحی‌های جوش‌دادن مهره‌ها با عوارض شدید و متعددی همراه بوده‌است.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000027358 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, Ozkaynak E, Oppermann H, Rueger DC (August 1990). "Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily". J. Biol. Chem. 265 (22): 13198–205. PMID 2376592. Archived from the original on 9 May 2005. Retrieved 16 March 2021.
↑ Chen D, Zhao M, Mundy GR (December 2004). "Bone morphogenetic proteins". Growth Factors. 22 (4): 233–41. doi:10.1080/08977190412331279890. PMID 15621726. S2CID 22932278.
↑ Marie PJ, Debiais F, Haÿ E (2002). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling". Histol. Histopathol. 17 (3): 877–85. doi:10.14670/HH-17.877. PMID 12168799.
↑ Jin W, Takagi T, Kanesashi SN, Kurahashi T, Nomura T, Harada J, Ishii S (April 2006). "Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins". Developmental Cell. 10 (4): 461–71. doi:10.1016/j.devcel.2006.02.016. PMID 16580992.
↑ Blázquez-Medela AM, Jumabay M, Boström KI (January 2019). "Beyond the bone: Bone morphogenetic protein signaling in adipose tissue". Obesity Reviews. 20 (5): 648–658. doi:10.1111/obr.12822. PMC 6447448. PMID 30609449.
↑ Urist MR (1965). "Bone: formation by autoinduction". Science. 150 (3698): 893–9. Bibcode:1965Sci...150..893U. doi:10.1126/science.150.3698.893. PMID 5319761. S2CID 83951938.
↑ Geiger M, Li RH, Friess W (November 2003). "Collagen sponges for bone regeneration with rhBMP-2". Adv. Drug Deliv. Rev. 55 (12): 1613–29. doi:10.1016/j.addr.2003.08.010. PMID 14623404.
↑ Khan SN, Lane JM (May 2004). "The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications". Expert Opin Biol Ther. 4 (5): 741–8. doi:10.1517/14712598.4.5.741. PMID 15155165. S2CID 45699304.
↑ Agrawal, V; Sinha, M. (2016). "A review on carrier systems for bone morphogenetic protein-2". Journal of Biomedical Materials Research Part B: Applied Biomaterials. Early View (4): 904–925. doi:10.1002/jbm.b.33599. PMID 26728994.
↑ Burkus JK, Gornet MF, Schuler TC, Kleeman TJ, Zdeblick TA (May 2009). "Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2". J Bone Joint Surg Am. 91 (5): 1181–9. doi:10.2106/JBJS.G.01485. PMID 19411467.
↑ Subach BR, Haid RW, Rodts GE, Kaiser MG (2001). "Bone morphogenetic protein in spinal fusion: overview and clinical update". Neurosurg Focus. 10 (4): 1–6. doi:10.3171/foc.2001.10.4.4. PMID 16732630.
↑ Allegrini S, Yoshimoto M, Salles MB, König B (February 2004). "Bone regeneration in rabbit sinus lifting associated with bovine BMP". Journal of Biomedical Materials Research Part B: Applied Biomaterials. 68 (2): 127–31. doi:10.1002/jbm.b.20006. PMID 14737759.
↑ Schlegel KA, Thorwarth M, Plesinac A, Wiltfang J, Rupprecht S (December 2006). "Expression of bone matrix proteins during the osseus healing of topical conditioned implants: an experimental study". Clin Oral Implants Res. 17 (6): 666–72. doi:10.1111/j.1600-0501.2006.01214.x. PMID 17092225.
↑ Schliephake H, Aref A, Scharnweber D, Bierbaum S, Roessler S, Sewing A (October 2005). "Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation". Clin Oral Implants Res. 16 (5): 563–9. doi:10.1111/j.1600-0501.2005.01143.x. PMID 16164462.
↑ Richter R (2011-06-28). "Medtronic's spinal fusion product shown to be harmful in bold review by medical journal and its Stanford editors". Inside Stanford Medicine. Stanford School of Medicine. Archived from the original on 2012-04-23. Retrieved 2012-06-25.
↑ Carragee EJ, Hurwitz EL, Weiner BK (June 2011). "A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned" (PDF). Spine J. 11 (6): 471–91. doi:10.1016/j.spinee.2011.04.023. PMID 21729796. Archived from the original (PDF) on 2011-11-10.

برای مطالعهٔ بیشتر

Nickel J, Dreyer MK, Kirsch T, Sebald W (2001). "The crystal structure of the BMP-2:BMPR-IA complex and the generation of BMP-2 antagonists". J Bone Joint Surg Am. 83-A Suppl 1 (Pt 1): S7–14. PMID 11263668.
Kawamura C, Kizaki M, Ikeda Y (2002). "Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells". Leuk. Lymphoma. 43 (3): 635–9. doi:10.1080/10428190290012182. PMID 12002771. S2CID 42810021.
Marie PJ, Debiais F, Haÿ E (2002). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling". Histol. Histopathol. 17 (3): 877–85. doi:10.14670/HH-17.877. PMID 12168799.

پیوند به بیرون

bone morphogenetic protein 2 در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم BMP2 انسانی و صفحهٔ جزئیات ژنی BMP2 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000027358 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_2376592-4] Sampath TK, Coughlin JE, Whetstone RM, Banach D, Corbett C, Ridge RJ, Ozkaynak E, Oppermann H, Rueger DC (August 1990). "Bovine osteogenic protein is composed of dimers of OP-1 and BMP-2A, two members of the transforming growth factor-beta superfamily". J. Biol. Chem. 265 (22): 13198–205. PMID 2376592. Archived from the original on 9 May 2005. Retrieved 16 March 2021.

[pmid_15621726-5] Chen D, Zhao M, Mundy GR (December 2004). "Bone morphogenetic proteins". Growth Factors. 22 (4): 233–41. doi:10.1080/08977190412331279890. PMID 15621726. S2CID 22932278.

[pmid_12168799-6] Marie PJ, Debiais F, Haÿ E (2002). "Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling". Histol. Histopathol. 17 (3): 877–85. doi:10.14670/HH-17.877. PMID 12168799.

[:0-7] Jin W, Takagi T, Kanesashi SN, Kurahashi T, Nomura T, Harada J, Ishii S (April 2006). "Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins". Developmental Cell. 10 (4): 461–71. doi:10.1016/j.devcel.2006.02.016. PMID 16580992.

[:1-8] Blázquez-Medela AM, Jumabay M, Boström KI (January 2019). "Beyond the bone: Bone morphogenetic protein signaling in adipose tissue". Obesity Reviews. 20 (5): 648–658. doi:10.1111/obr.12822. PMC 6447448. PMID 30609449.

[urist1965-9] Urist MR (1965). "Bone: formation by autoinduction". Science. 150 (3698): 893–9. Bibcode:1965Sci...150..893U. doi:10.1126/science.150.3698.893. PMID 5319761. S2CID 83951938.

[pmid_14623404-10] Geiger M, Li RH, Friess W (November 2003). "Collagen sponges for bone regeneration with rhBMP-2". Adv. Drug Deliv. Rev. 55 (12): 1613–29. doi:10.1016/j.addr.2003.08.010. PMID 14623404.

[pmid_15155165-11] Khan SN, Lane JM (May 2004). "The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications". Expert Opin Biol Ther. 4 (5): 741–8. doi:10.1517/14712598.4.5.741. PMID 15155165. S2CID 45699304.

[AgrawalARev16-12] Agrawal, V; Sinha, M. (2016). "A review on carrier systems for bone morphogenetic protein-2". Journal of Biomedical Materials Research Part B: Applied Biomaterials. Early View (4): 904–925. doi:10.1002/jbm.b.33599. PMID 26728994.

[pmid_19411467-13] Burkus JK, Gornet MF, Schuler TC, Kleeman TJ, Zdeblick TA (May 2009). "Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2". J Bone Joint Surg Am. 91 (5): 1181–9. doi:10.2106/JBJS.G.01485. PMID 19411467.

[pmid_16732630-14] Subach BR, Haid RW, Rodts GE, Kaiser MG (2001). "Bone morphogenetic protein in spinal fusion: overview and clinical update". Neurosurg Focus. 10 (4): 1–6. doi:10.3171/foc.2001.10.4.4. PMID 16732630.

[pmid_14737759-15] Allegrini S, Yoshimoto M, Salles MB, König B (February 2004). "Bone regeneration in rabbit sinus lifting associated with bovine BMP". Journal of Biomedical Materials Research Part B: Applied Biomaterials. 68 (2): 127–31. doi:10.1002/jbm.b.20006. PMID 14737759.

[pmid_17092225-16] Schlegel KA, Thorwarth M, Plesinac A, Wiltfang J, Rupprecht S (December 2006). "Expression of bone matrix proteins during the osseus healing of topical conditioned implants: an experimental study". Clin Oral Implants Res. 17 (6): 666–72. doi:10.1111/j.1600-0501.2006.01214.x. PMID 17092225.

[pmid_16164462-17] Schliephake H, Aref A, Scharnweber D, Bierbaum S, Roessler S, Sewing A (October 2005). "Effect of immobilized bone morphogenic protein 2 coating of titanium implants on peri-implant bone formation". Clin Oral Implants Res. 16 (5): 563–9. doi:10.1111/j.1600-0501.2005.01143.x. PMID 16164462.

[18] Richter R (2011-06-28). "Medtronic's spinal fusion product shown to be harmful in bold review by medical journal and its Stanford editors". Inside Stanford Medicine. Stanford School of Medicine. Archived from the original on 2012-04-23. Retrieved 2012-06-25.

[pmid_21729796-19] Carragee EJ, Hurwitz EL, Weiner BK (June 2011). "A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned" (PDF). Spine J. 11 (6): 471–91. doi:10.1016/j.spinee.2011.04.023. PMID 21729796. Archived from the original (PDF) on 2011-11-10.