پروتئین ۱۰ ریخت‌زایی استخوان

BMP10
معین‌کننده‌ها
نام‌های دیگر	BMP10, entrez:27302, bone morphogenetic protein 10
شناسه‌های بیرونی	OMIM: 608748 MGI: 1338820 HomoloGene: 7644 GeneCards: BMP10
موقعیت ژن (موش)
کروموزوم	کروموزوم ۶ (موش)
پایان	87,414,659 bp
هستی‌شناسی ژن
عملکرد ملکولی	• cytokine activity; • receptor serine/threonine kinase binding; • hormone activity; • telethonin binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • transforming growth factor beta receptor binding; • growth factor activity;
ترکیبات سلولی	• سیتوپلاسم; • extracellular region; • cell surface; • Z disc; • extracellular space;
فرایند زیستی	• regulation of apoptotic process; • pathway-restricted SMAD protein phosphorylation; • regulation of MAPK cascade; • heart trabecula formation; • SMAD protein signal transduction; • negative regulation of cardiac muscle hypertrophy; • adult heart development; • positive regulation of pathway-restricted SMAD protein phosphorylation; • positive regulation of sarcomere organization; • positive regulation of cell proliferation involved in heart morphogenesis; • cardiac muscle cell proliferation; • positive regulation of cardiac muscle hypertrophy; • negative regulation of endothelial cell migration; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • ventricular cardiac muscle tissue morphogenesis; • multicellular organism development; • heart development; • GO:1901313 positive regulation of gene expression; • چسبندگی سلولی; • negative regulation of cell migration; • positive regulation of cardiac muscle cell proliferation; • positive regulation of cartilage development; • negative regulation of cell growth; • regulation of cardiac muscle hypertrophy in response to stress; • atrial cardiac muscle tissue morphogenesis; • regulation of cardiac muscle contraction; • sarcomere organization; • ventricular cardiac muscle cell development; • activin receptor signaling pathway; • BMP signaling pathway; • regulation of signaling receptor activity; • cell development;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	27302
	12154
	ENSG00000163217
	ENSMUSG00000030046
	O95393
	Q9R229
	NM_014482
	NM_009756
	NP_055297
	NP_033886
	مشاهده/ویرایش موش

پروتئین ۱۰ ریخت‌زایی استخوان (انگلیسی: Bone morphogenetic protein 10) یک پروتئین است که در انسان توسط ژن «BMP10» کُدگذاری می‌شود.

این پروتئین عضوی از خانوادهٔ فاکتور رشد تغییردهنده بتا است. پروتئین‌های ریخت‌زایی استخوان قادرند رشد و تکامل غضروف و استخوان را تحریک کنند. پروتئین ۱۰ ریخت‌زایی استخوان بر خلاف سایر اعضای این خانواده، در ایجاد تورتیغه‌های قلب (ترابکولاسیون قلب) هم نقش دارد.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000030046 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: bone morphogenetic protein 10".
↑ Neuhaus H, Rosen V, Thies RS (February 1999). "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mech. Dev. 80 (2): 181–4. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785. S2CID 15626081.

برای مطالعهٔ بیشتر

Davila S; Froeling FE; Tan A; et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Hillier LW; Graves TA; Fulton RS; et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Mazerbourg S; Sangkuhl K; Luo CW; et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nakano N; Hori H; Abe M; et al. (2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". Am. J. Physiol. Heart Circ. Physiol. 293 (6): H3396–403. doi:10.1152/ajpheart.00311.2007. PMID 17921333.
Marroni F; Pfeufer A; Aulchenko YS; et al. (2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circ Cardiovasc Genet. 2 (4): 322–8. doi:10.1161/CIRCGENETICS.108.833806. PMC 2760953. PMID 20031603.
Strausberg RL; Feingold EA; Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
David L; Mallet C; Mazerbourg S; et al. (2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood. 109 (5): 1953–61. doi:10.1182/blood-2006-07-034124. PMID 17068149.

پیوند به بیرون

مکان ژنوم BMP10 انسانی و صفحهٔ جزئیات ژنی BMP10 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000030046 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: bone morphogenetic protein 10".

[pmid10072785-5] Neuhaus H, Rosen V, Thies RS (February 1999). "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mech. Dev. 80 (2): 181–4. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785. S2CID 15626081.