بتا-کاتنین

CTNNB1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1G3J, 1JDH, 1JPW, 1LUJ, 1P22, 1QZ7, 1T08, 1TH1, 2GL7, 2Z6H, 3DIW, 3SL9, 3SLA, 3TX7, 4DJS, 3FQN, 3FQR
معین‌کننده‌ها
نام‌های دیگر	CTNNB1, CTNNB, MRD19, armadillo, catenin beta 1, EVR7, NEDSDV
شناسه‌های بیرونی	OMIM: 116806 MGI: 88276 HomoloGene: 1434 GeneCards: CTNNB1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۹ (موش)
پایان	120,789,573 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • DNA binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • SMAD binding; • chromatin binding; • signal transducer activity; • double-stranded DNA binding; • protein C-terminus binding; • protein kinase binding; • kinase binding; • androgen receptor binding; • transmembrane transporter binding; • estrogen receptor binding; • I-SMAD binding; • protein phosphatase binding; • transcription factor binding; • GO:0001105 transcription coactivator activity; • alpha-catenin binding; • enzyme binding; • RNA polymerase II core promoter sequence-specific DNA binding; • protein heterodimerization activity; • cadherin binding; • disordered domain specific binding;
ترکیبات سلولی	• adherens junction; • beta-catenin destruction complex; • protein-DNA complex; • پای‌لایه; • beta-catenin-TCF complex; • beta-catenin-TCF7L2 complex; • میان‌تن; • Z disc; • bicellular tight junction; • transcription regulator complex; • lateral plasma membrane; • سیتوپلاسم; • cell cortex; • apical part of cell; • spindle pole; • Scrib-APC-beta-catenin complex; • catenin-TCF7L2 complex; • flotillin complex; • intercalated disc; • هسته یاخته; • cell-cell junction; • membrane; • Wnt signalosome; • basolateral plasma membrane; • پوسته یاخته; • اسکلت سلولی; • extracellular exosome; • نوکلئوپلاسم; • microtubule organizing center; • cell periphery; • apical junction complex; • cell projection membrane; • focal adhesion; • microvillus membrane; • fascia adherens; • سیتوزول; • پیوند میان‌یاخته‌ای; • perinuclear region of cytoplasm; • catenin complex; • سیناپس; • intracellular anatomical structure; • GO:0009327 protein-containing complex; • presynaptic membrane; • cell projection; • postsynaptic membrane; • Schaffer collateral - CA1 synapse; • presynaptic active zone cytoplasmic component; • postsynaptic density, intracellular component;
فرایند زیستی	• embryonic brain development; • negative regulation of cell population proliferation; • renal vesicle formation; • positive regulation of MAPK cascade; • proximal/distal pattern formation; • positive regulation of neuroblast proliferation; • chemical synaptic transmission; • central nervous system vasculogenesis; • renal inner medulla development; • transcription, DNA-templated; • positive regulation of neuron apoptotic process; • canonical Wnt signaling pathway; • embryonic foregut morphogenesis; • endoderm formation; • endodermal cell fate commitment; • synapse organization; • trachea formation; • GO:0006928 cellular process; • positive regulation of telomere maintenance via telomerase; • neural plate development; • negative regulation of protein sumoylation; • lung cell differentiation; • vasculogenesis; • lung induction; • هماتوپوئز; • kidney development; • GO:1901313 positive regulation of gene expression; • adherens junction organization; • renal outer medulla development; • thymus development; • regulation of myelination; • positive regulation of cell population proliferation; • epithelial tube branching involved in lung morphogenesis; • bone resorption; • epithelial cell differentiation involved in prostate gland development; • regulation of euchromatin binding; • hair follicle morphogenesis; • hair follicle placode formation; • neuron migration; • negative regulation of chondrocyte differentiation; • fungiform papilla formation; • positive regulation of type I interferon production; • negative regulation of mitotic cell cycle, embryonic; • ectoderm development; • trachea morphogenesis; • T cell differentiation in thymus; • pancreas development; • cranial ganglion development; • regulation of apoptotic process; • lung development; • positive regulation of skeletal muscle tissue development; • synaptic vesicle transport; • positive regulation of telomerase activity; • morphogenesis of embryonic epithelium; • renal system development; • oocyte development; • hair cycle process; • embryonic axis specification; • embryonic forelimb morphogenesis; • anterior/posterior axis specification; • positive regulation of endothelial cell differentiation; • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II; • animal organ development; • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; • dorsal/ventral axis specification; • positive regulation of muscle cell differentiation; • positive regulation of apoptotic process; • regulation of protein localization to cell surface; • androgen receptor signaling pathway; • جنین‌شناسی دستگاه عصبی مرکزی; • forebrain development; • hair cell differentiation; • GO:1901227 negative regulation of transcription by RNA polymerase II; • regulation of epithelial cell differentiation; • positive regulation of histone H3-K4 methylation; • embryonic digit morphogenesis; • endothelial tube morphogenesis; • osteoclast differentiation; • GO:0009373 regulation of transcription, DNA-templated; • regulation of osteoclast differentiation; • neuron differentiation; • گذار اپیتلیال-مزانشیمی; • cell fate specification; • odontogenesis of dentin-containing tooth; • midbrain development; • positive regulation of mesenchymal cell proliferation; • positive regulation of heparan sulfate proteoglycan biosynthetic process; • smooth muscle cell differentiation; • glial cell fate determination; • cell fate determination; • positive regulation of determination of dorsal identity; • regulation of T cell proliferation; • gastrulation with mouth forming second; • negative regulation of apoptotic signaling pathway; • oviduct development; • cellular response to growth factor stimulus; • male genitalia development; • negative regulation of gene expression; • nephron tubule formation; • regulation of osteoblast differentiation; • regulation of angiogenesis; • cell morphogenesis involved in differentiation; • cell-matrix adhesion; • dorsal root ganglion development; • regulation of cell population proliferation; • embryonic skeletal limb joint morphogenesis; • heart development; • T cell differentiation; • dorsal/ventral pattern formation; • layer formation in cerebral cortex; • canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation; • canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition; • positive regulation of osteoblast differentiation; • negative regulation of osteoclast differentiation; • regulation of core promoter binding; • genitalia morphogenesis; • negative regulation of neuron death; • cell maturation; • cell population proliferation; • branching involved in ureteric bud morphogenesis; • دگرگونی یاخته‌; • protein localization to cell surface; • embryonic hindlimb morphogenesis; • negative regulation of oligodendrocyte differentiation; • metanephros morphogenesis; • regulation of centriole-centriole cohesion; • limb development; • positive regulation of epithelial cell proliferation involved in prostate gland development; • regulation of secondary heart field cardioblast proliferation; • regulation of fibroblast proliferation; • regulation of smooth muscle cell proliferation; • skin development; • skeletal system development; • hindbrain development; • regulation of calcium ion import; • mesenchymal cell proliferation involved in lung development; • regulation of nephron tubule epithelial cell differentiation; • cellular response to indole-3-methanol; • canonical Wnt signaling pathway involved in negative regulation of apoptotic process; • ساماندهی بیان ژن; • regulation of cell differentiation; • stem cell population maintenance; • regulation of neurogenesis; • in utero embryonic development; • lung-associated mesenchyme development; • negative regulation of cell differentiation; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • vasculature development; • sympathetic ganglion development; • positive regulation of epithelial cell differentiation; • positive regulation of branching involved in lung morphogenesis; • lens morphogenesis in camera-type eye; • positive regulation of epithelial to mesenchymal transition; • positive regulation of fibroblast growth factor receptor signaling pathway; • embryonic heart tube development; • regulation of centromeric sister chromatid cohesion; • positive regulation of DNA-templated transcription, initiation; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • branching involved in blood vessel morphogenesis; • positive regulation of DNA-binding transcription factor activity; • چسبندگی سلولی; • GO:0045996 negative regulation of transcription, DNA-templated; • adherens junction assembly; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • Wnt signaling pathway, calcium modulating pathway; • beta-catenin-TCF complex assembly; • beta-catenin destruction complex disassembly; • cranial skeletal system development; • proteasome-mediated ubiquitin-dependent protein catabolic process; • Wnt signaling pathway; • canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation; • response to estradiol; • midbrain dopaminergic neuron differentiation; • entry of bacterium into host cell; • negative regulation of oxidative stress-induced neuron death; • positive regulation of core promoter binding; • GO:0022415 viral process; • negative regulation of angiogenesis; • negative regulation of epithelial cell differentiation; • negative regulation of apoptotic process; • positive regulation of molecular function; • positive regulation of epithelial cell proliferation; • negative regulation of neurogenesis; • regulation of timing of anagen; • regulation of canonical Wnt signaling pathway; • synaptic vesicle clustering; • cell-cell adhesion; • neuron projection extension; • positive regulation of neural precursor cell proliferation; • protein polyubiquitination; • tissue homeostasis;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1499
	12387
	ENSG00000168036
	ENSMUSG00000006932
	P35222
	Q02248
	NM_001098209، NM_001098210، NM_001904، XM_006712983، XM_017005738، NM_001330729، XM_024453356، XM_024453357، XM_024453358، XM_024453359، XM_024453360 XM_006712985، NM_001098209، NM_001098210، NM_001904، XM_006712983، XM_017005738، NM_001330729، XM_024453356، XM_024453357، XM_024453358، XM_024453359، XM_024453360
	NM_007614 NM_001165902، NM_007614
	NP_001091680، NP_001317658، NP_001895، XP_006713046، XP_006713048، XP_016861227، XP_024309124، XP_024309125، XP_024309126، XP_024309127، XP_024309128 NP_001091679، NP_001091680، NP_001317658، NP_001895، XP_006713046، XP_006713048، XP_016861227، XP_024309124، XP_024309125، XP_024309126، XP_024309127، XP_024309128
	NP_031640 NP_001159374، NP_031640
	مشاهده/ویرایش موش

بتا-کاتنین (انگلیسی: β-catenin) نام یک پروتئین است که در انسان توسط ژن «CTNNB1» کُد می‌شود. بتا-کاتنین یک پروتئین دوکاره است که در تنظیم و هماهنگی چسبندگی سلول‌به‌سلول و همچنین رونویسی ژن‌ها نقش دارد.

تصویر ساده‌شده‌ای از ساختارِ بتا-کاتنین.

هومولوگ این پروتئین در مگس سرکه، «آرمادیلو» نامیده می‌شود. بتا-کاتنین یکی از زیرواحدهای کمپلکس پروتئینی کادهرین است و به‌عنوان یک فرستندهٔ سیگنال درون سلولی در «مسیر سیگنال‌دهی Wnt» عمل می‌کند.

بتا-کاتنین در بسیاری از بافت‌های بدن تولید می‌شود.

جهش و افزایش بیان ژنی این پروتئین با سرطان‌های گوناگونی مرتبط است، از جمله کارسینوم هپاتوسلولار (کبد)، سرطان پستان، سرطان روده بزرگ، سرطان ریه، سرطان تخمدان و سرطان مخاط رحم.

همچنین تغییرات بیان ژنی این پروتئین با بسیاری از بیماری قلبی-عروقی از جمله «کاردیومیوپاتی گشادشده» (DCM).

بتا-کاتنین توسط «کمپلکس تخریب بتا-کاتنین» و همچنین پروتئین «APC» کنترل و تخریب می‌شود. در نتیجه هرگونه جهش در ژن «APC»، ارتباط نزدیکی با بروز برخی سرطان‌ها، به‌ویژه «سرطان روده بزرگ» و «پولیپوز آدنوماتوز خانوادگی» دارد.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000006932 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kraus C, Liehr T, Hülsken J, Behrens J, Birchmeier W, Grzeschik KH, Ballhausen WG (September 1994). "Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development". Genomics. 23 (1): 272–4. doi:10.1006/geno.1994.1493. PMID 7829088.
↑ MacDonald BT, Tamai K, He X (July 2009). "Wnt/beta-catenin signaling: components, mechanisms, and diseases". Developmental Cell. 17 (1): 9–26. doi:10.1016/j.devcel.2009.06.016. PMC 2861485. PMID 19619488.
↑ Peifer M, Rauskolb C, Williams M, Riggleman B, Wieschaus E (April 1991). "The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation". Development. 111 (4): 1029–43. PMID 1879348.
↑ Noordermeer J, Klingensmith J, Perrimon N, Nusse R (January 1994). "dishevelled and armadillo act in the wingless signalling pathway in Drosophila". Nature. 367 (6458): 80–3. doi:10.1038/367080a0. PMID 7906389.
↑ Peifer M, Berg S, Reynolds AB (March 1994). "A repeating amino acid motif shared by proteins with diverse cellular roles". Cell. 76 (5): 789–91. doi:10.1016/0092-8674(94)90353-0. PMID 7907279.
↑ Morin PJ (December 1999). "beta-catenin signaling and cancer". BioEssays. 21 (12): 1021–30. doi:10.1002/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P. PMID 10580987.

پیوند به بیرون

beta Catenin در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
مکان ژنوم CTNNB1 انسانی و صفحهٔ جزئیات ژنی CTNNB1 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000006932 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_7829088-4] Kraus C, Liehr T, Hülsken J, Behrens J, Birchmeier W, Grzeschik KH, Ballhausen WG (September 1994). "Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development". Genomics. 23 (1): 272–4. doi:10.1006/geno.1994.1493. PMID 7829088.

[pmid_19619488-5] MacDonald BT, Tamai K, He X (July 2009). "Wnt/beta-catenin signaling: components, mechanisms, and diseases". Developmental Cell. 17 (1): 9–26. doi:10.1016/j.devcel.2009.06.016. PMC 2861485. PMID 19619488.

[pmid_1879348-6] Peifer M, Rauskolb C, Williams M, Riggleman B, Wieschaus E (April 1991). "The segment polarity gene armadillo interacts with the wingless signaling pathway in both embryonic and adult pattern formation". Development. 111 (4): 1029–43. PMID 1879348.

[pmid_7906389-7] Noordermeer J, Klingensmith J, Perrimon N, Nusse R (January 1994). "dishevelled and armadillo act in the wingless signalling pathway in Drosophila". Nature. 367 (6458): 80–3. doi:10.1038/367080a0. PMID 7906389.

[pmid_7907279-8] Peifer M, Berg S, Reynolds AB (March 1994). "A repeating amino acid motif shared by proteins with diverse cellular roles". Cell. 76 (5): 789–91. doi:10.1016/0092-8674(94)90353-0. PMID 7907279.

[9] Morin PJ (December 1999). "beta-catenin signaling and cancer". BioEssays. 21 (12): 1021–30. doi:10.1002/(SICI)1521-1878(199912)22:1<1021::AID-BIES6>3.0.CO;2-P. PMID 10580987.