بتا-مانوزیداز

MANBA
معین‌کننده‌ها
نام‌های دیگر	MANBA, MANB1, mannosidase beta
شناسه‌های بیرونی	OMIM: 609489 MGI: 88175 HomoloGene: 4317 GeneCards: MANBA
موقعیت ژن (موش)
کروموزوم	کروموزوم ۳ (موش)
پایان	135,277,165 bp
هستی‌شناسی ژن
عملکرد ملکولی	• hydrolase activity; • hydrolase activity, hydrolyzing O-glycosyl compounds; • mannose binding; • hydrolase activity, acting on glycosyl bonds; • beta-mannosidase activity;
ترکیبات سلولی	• کافنده‌تن; • lysosomal lumen; • پوسته یاخته; • azurophil granule membrane; • intracellular membrane-bounded organelle;
فرایند زیستی	• دگرگشت; • oligosaccharide catabolic process; • neutrophil degranulation; • سوخت‌وساز کربوهیدرات; • glycoprotein catabolic process; • mannan catabolic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	4126
	110173
	ENSG00000109323
	ENSMUSG00000028164
	O00462
	Q8K2I4
	XM_017008203، XM_017008204، XM_017008205، XM_024454048، XM_024454049 NM_005908، XM_017008203، XM_017008204، XM_017008205، XM_024454048، XM_024454049
	XM_006500908، XR_867210 NM_027288، XM_006500908، XR_867210
	XP_016863692، XP_016863693، XP_016863694، XP_024309816، XP_024309817 NP_005899، XP_016863692، XP_016863693، XP_016863694، XP_024309816، XP_024309817
	XP_006500971 NP_081564، XP_006500971
	مشاهده/ویرایش موش

بتا-مانوزیداز (انگلیسی: Beta-mannosidase) یک آنزیم است که در انسان توسط ژن «MANBA» کُدگذاری می‌شود.

این آنزیم سبب هیدرولیز ریشه‌های غیراحیاکنندهٔ انتهایی بتا-دی-مانوز در مولکول‌های بتا-دی-مانوزیدها می‌گردد. این آنزیم یکی از اعضای خانوادهٔ بزرگ گلیکوزیل هیدرولیز ۲ محسوب می‌شود و در درون لیزوزوم سلول‌ها جای دارد.

جهش در ژن سازندهٔ این آنزیم سبب بروز نوعی بیماری ذخیرهٔ لیزوزومی به نام «بتا-مانوزیدوزیس» می‌گردد که طیف گسترده‌ای از علائم مغزی-عصبی را شامل می‌شود.

منابع

↑ GRCm38: Ensembl release 89: ENSMUSG00000028164 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: mannosidase".
↑ Chen H, Leipprandt JR, Traviss CE, Sopher BL, Jones MZ, Cavanagh KT, Friderici KH (February 1995). "Molecular cloning and characterization of bovine beta-mannosidase". J. Biol. Chem. 270 (8): 3841–8. doi:10.1074/jbc.270.8.3841. PMID 7876128.
↑ Adams, M.; Richtmyer, N.K. & Hudson, C.S. (1943). "Some enzymes present in highly purified invertase preparations; a contribution to the study of fructofuranosidases, galactosidases, glucosidases and mannosidases". J. Am. Chem. Soc. 65 (7): 1369–1380. doi:10.1021/ja01247a029.
↑ Bartholomew, B.A. & Perry, A.L. (1973). "The properties of synovial fluid β-mannosidase activity". Biochim. Biophys. Acta. 315 (1): 123–127. doi:10.1016/0005-2744(73)90136-8. PMID 4743897.
↑ Deuel, H.; Lewuenberger, R. & Huber, G. (1950). "Über den enzymatischen Abbau von Carubin, dem Galaktomannan aus Ceratonia siliqua L". Helv. Chim. Acta. 33 (4): 942–946. doi:10.1002/hlca.19500330424.
↑ Hylin, J.W. & Sawai, K. (1964). "The enzymatic hydrolysis of Leucaena glauca galactomannan. Isolation of crystalline galactomannan depolymerase". J. Biol. Chem. 239: 990–992. PMID 14165949.

برای مطالعهٔ بیشتر

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پیوند به بیرون

مکان ژنوم MANBA انسانی و صفحهٔ جزئیات ژنی MANBA در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.
خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q8K2I4 (Mouse Beta-mannosidase) در PDBe-KB.

[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000028164 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: mannosidase".

[pmid7876128-5] Chen H, Leipprandt JR, Traviss CE, Sopher BL, Jones MZ, Cavanagh KT, Friderici KH (February 1995). "Molecular cloning and characterization of bovine beta-mannosidase". J. Biol. Chem. 270 (8): 3841–8. doi:10.1074/jbc.270.8.3841. PMID 7876128.

[6] Adams, M.; Richtmyer, N.K. & Hudson, C.S. (1943). "Some enzymes present in highly purified invertase preparations; a contribution to the study of fructofuranosidases, galactosidases, glucosidases and mannosidases". J. Am. Chem. Soc. 65 (7): 1369–1380. doi:10.1021/ja01247a029.

[7] Bartholomew, B.A. & Perry, A.L. (1973). "The properties of synovial fluid β-mannosidase activity". Biochim. Biophys. Acta. 315 (1): 123–127. doi:10.1016/0005-2744(73)90136-8. PMID 4743897.

[8] Deuel, H.; Lewuenberger, R. & Huber, G. (1950). "Über den enzymatischen Abbau von Carubin, dem Galaktomannan aus Ceratonia siliqua L". Helv. Chim. Acta. 33 (4): 942–946. doi:10.1002/hlca.19500330424.

[9] Hylin, J.W. & Sawai, K. (1964). "The enzymatic hydrolysis of Leucaena glauca galactomannan. Isolation of crystalline galactomannan depolymerase". J. Biol. Chem. 239: 990–992. PMID 14165949.